Results 241 to 250 of about 25,360 (296)

Fumarate and Its Esters: Physiology, Pathology, Molecular Mechanisms, Diseases, and Therapy

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Fumarate is an endogenous immunometabolite that regulates metabolism, redox homeostasis, and inflammation. Although fumaric acid esters (FAEs) share several molecular targets with fumarate, their distinct physicochemical properties confer unique biological activities and therapeutic applications.
Peng Zhu   +6 more
wiley   +1 more source

Neuropathic Pain: From Mechanisms to Therapeutic Interventions

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Neuropathic pain arises from peripheral nerve injury, central sensitization, neurotransmitter imbalance, neuroimmune activation, and maladaptive circuit remodeling. Clinical phenotyping and multimodal imaging can identify dominant peripheral and central mechanisms.
Yaling Dai   +8 more
wiley   +1 more source

Advanced Glycation End Products: From Pathogenesis to Treatment

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Therapeutic landscape of AGE‐targeted intervention. Schematic representation of intervention strategies targeting distinct stages of AGE biology. Upstream prevention aims to reduce exposure and formation through low‐AGE cooking, smoking cessation, glycemic control, and metabolic optimization.
Tak‐Ho Lo   +7 more
wiley   +1 more source

Developing a core outcome set for sciatica: a scoping review of outcome measures. [PDF]

open access: yesBMJ Open
Ridsdale K   +6 more
europepmc   +1 more source

Saudi Clinical Practice Guideline for the Assessment and Management of Low Back Pain and Sciatica in Adults. [PDF]

open access: yesJ Clin Med
Aldera M   +16 more
europepmc   +1 more source

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