Results 111 to 120 of about 192,238 (309)

Identity development in adolescents with mental problems [PDF]

, 2013
Background: In the revision of the Diagnostic and Statistical Manual (DSM-5), "Identity" is an essential diagnostic criterion for personality disorders (self-related personality functioning) in the alternative approach to the diagnosis of personality ...
Goth, Kirstin, Jung, Emanuel, Pick, Oliver, Schlüter-Müller, Susanne, Schmeck, Klaus   +4 more
core   +1 more source

Advances in radiopharmaceuticals for cancer radiotheranostics: CCK2R targeting as a paradigm for translational innovation

Cancer Communications, EarlyView.
Abstract Radiopharmaceuticals are reshaping the landscape of cancer therapy, offering a unique theranostic advantage that is becoming increasingly central to precision medicine. By labeling the same molecular scaffold with different radionuclides, these agents enable seamless integration of diagnostic imaging and targeted therapy.
Jing Li, Xuejun Wen, Rebeka Rita Reszegi, Hemavarshini Kamalrhaj, Wolfgang J. Parak, Xiaoyuan Chen, Jingjing Zhang   +6 more
wiley   +1 more source

Development of a novel rodent model for dog heartworm microfilaremia using the severe-combined immunodeficiency mouse

Scientific Reports
Dirofilaria immitis is a mosquito-borne parasitic nematode that causes fatal heartworm disease in canids. The microfilariae are essential for research, including drug screening and mosquito-parasite interactions.
Mihoko Mizuseki, Nao Ikeda, Takahiro Shirozu, Maki Yamagishi, Sugao Oshiro, Shinya Fukumoto   +5 more
doaj   +1 more source

Design and Characterization of Prodrugged Anti‐CTLA‐4 Antibodies

ChemBioChem, EarlyView.
Masking an anti‐CTLA‐4 antibody by conjugating a large PEG molecule to specific sites is explored as a way of mitigating undesirable activity in nontarget tissues. This prodrugged antibody exhibits reduced binding to CTLA‐4 and Fc gamma receptors, demonstrated high stability, and had an extended half‐life in a mouse model, potentially improving the ...
Sayumi Yamazoe, Mary Huber, Srikanth Kotapati, Rahima Akter, Aarti Jashnani, Suprit Deol, Christine Bee, John Engelhart, Yam B. Poudel, Stanley Krystek, John Haugner, Mohan Srinivasan, Arvind Rajpal, Yong Zhang, Pavel Strop, Chetana Rao   +15 more
wiley   +1 more source

860. Long-Term Preclinical Evaluation of Lentiviral Vectors for SCID-X1 Gene Therapy in a SCID-X1 Mouse Model [PDF]

, 2010

openalex   +1 more source

Measuring Implicit Approach‐Avoidance Tendencies Using Self‐Depicting Body Pictures in Female Adults With Bulimia Nervosa, High Body Dissatisfaction and Healthy Controls

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Body dissatisfaction is an important factor for the etiology and maintenance of eating disorders such as bulimia nervosa (BN). At the behavioral level, body dissatisfaction often manifests itself in excessive body‐related avoidance, thought to act as a negative reinforcer.
Johanna Xemaire, Ines Wolz, Dustin Werle, Carolin Dudschig, Jennifer Svaldi   +4 more
wiley   +1 more source

Targeted delivery of anti-inflammatory therapy to rheumatoid tissue by fusion proteins containing an IL-4-linked synovial targeting peptide [PDF]

, 2011
We provide first-time evidence that the synovial endothelium-targeting peptide (SyETP) CKSTHDRLC successfully delivers conjugated IL-4 to human rheumatoid synovium transplanted into SCID mice. SyETP, previously isolated by in vivo phage display and shown
Ahuva Nissim, Ciara M. Finucane, Costantino Pitzalis, Danielle DiCara, Michele Bombardieri, Rita Jones, Sarah E. Wythe, Stephen J. Mather, Taher E. I. Taher, Y. K. Stella Man, Yuti Chernajovsky   +10 more
core   +1 more source

Nuclease-free Adeno-Associated Virus-Mediated Il2rg Gene Editing in X-SCID Mice [PDF]

, 2018
Takafumi Hiramoto, Li B. Li, Sarah E. Funk, Roli K. Hirata, David W. Russell   +4 more
openalex   +1 more source

General and Symptom‐Specific Illness Duration and Course as Predictors of Symptom Severity in Anorexia Nervosa

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Illness duration has been examined as a predictor of anorexia nervosa (AN) outcomes to mixed results, yet is frequently used to make treatment and prognosis decisions. More specific metrics, such as prior illness course (e.g., continuous vs.
Kira G. Venables, Ariana R. Bazzi, Abigail Smith, Soo‐Eun Lee, Carol B. Peterson, Ann F. Haynos   +5 more
wiley   +1 more source

Rare Biallelic Variants Affecting the Interdomain B Region of Zeta-Chain Associated Protein Kinase 70 (ZAP70) Protein in a Sudanese Patient: Case Report

International Medical Case Reports Journal
Alamin Mustafa,1 Rogaia Hasap Alrasoul Ahmed,2 Hala Hamza Eltayeb,2 Malaz Elsadeg,2 Omaima Abdel Majeed Mohamed Salih,3 Nahla HH Erwa4 1Al-Neelain University, Faculty of Medicine, Khartoum, Sudan; 2Faculty of Medicine, Omdurman Islamic University ...
Mustafa A, Ahmed RHA, Eltayeb HH, Elsadeg M, Salih OAMM, Erwa NHH   +5 more
doaj