Results 121 to 130 of about 102,493 (259)

A comprehensive evaluation of the human Tg32 and Tg276 FcRn transgenic mouse and non-human primate models for predicting antibody pharmacokinetics in human. [PDF]

MAbs
Gajewska M, Kiffe M, Calonder C, Engelhardt V, Pou I Miralbell C, Gonzalo-Gil E, Christianson G, Bethur N, Flora A.   +8 more
europepmc   +1 more source

BCL‐2 and MCL1 co‐inhibition enhances glucocorticoid therapy in preclinical models of infant KMT2A‐rearranged acute lymphoblastic leukaemia

British Journal of Haematology, EarlyView.
Mawar Karsa, Ayu Karsa, Dayna Spurling, Lin Xiao, Emma Ronca, Angelika Bongers, Weiman Gao, Andrew J. Gifford, Ali El‐Ayoubi, Laurence C. Cheung, Rishi S. Kotecha, Richard B. Lock, Charis E. Teh, Guillaume Lessene, Murray D. Norris, Andrew Wei, Michelle Haber, Michelle J. Henderson, Donia M. Moujalled, Klaartje Somers   +19 more
wiley   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Identification of novel <i>JAK3</i> variants in a suspected SCID patient and two couples undergoing carrier screening. [PDF]

Front Genet
Peng Y, Sang YL, Zhu W, Zhang N, Sun Y, Lin G, Lu GX, Tan YQ, Du J, Wang FY, He WB.   +10 more
europepmc   +1 more source

Mental Health Disorders in End‐Stage Kidney Disease: A Narrative Review of Clinical Considerations for Integrated Management

Hemodialysis International, EarlyView.
ABSTRACT Introduction End stage kidney disease (ESKD) is associated with a high prevalence of depression and anxiety, arising from both biological factors and the psychosocial burden of chronic dialysis care. Approximately 25%–30% of dialysis patients experience clinically significant depressive symptoms when assessed by structured clinical interview ...
Kunal Malhotra, Jordan Fangue‐Nelon, Garima Singh   +2 more
wiley   +1 more source

Modeling and correction of SCID-X1 using CRISPR-Cas9 homology-directed repair in human HSPCs. [PDF]

Mol Ther Nucleic Acids
Knop O, Ben Haim N, Kalter N, Rosenberg M, Breier D, Baider K, Lee YN, Adam E, Somekh I, Nagler A, Somech R, Hendel A.   +11 more
europepmc   +1 more source

Optimal Hypoxia Mimetic Small Molecules for Enhancing Angiogenic Properties of Stem Cells From Human Exfoliated Deciduous Teeth

International Endodontic Journal, EarlyView.
ABSTRACT Aim Hypoxic preconditioning of cells holds promise for regenerative therapies, yet identifying effective and safe methods for clinical application remains challenging. We aimed to determine optimal hypoxia‐mimetic small molecules (SMs) that stabilize hypoxia‐inducible factor‐1α (HIF‐1α) and their dosages for hypoxic preconditioning in stem ...
Hong Wang, Jiawei Liu, Xintao Yang, Mohamad Koohi‐Moghadam, Shuting Gao, Yuanyuan Han, Dineshi Sewvandi Thalakiriyawa, James Kit Hon Tsoi, Yanqi Yang, Waruna Lakmal Dissanayaka   +9 more
wiley   +1 more source

Parental Views on the Psychosocial Impact of False-Positive Results Following Newborn Screening for Severe Combined Immunodeficiency in England. [PDF]

Int J Neonatal Screen
Holder P, Musa C, Keetharuth A, Ulph F, Chilcott JB, Moody L, Olander EK, Chudleigh J.   +7 more
europepmc   +1 more source

Mental disorder trajectories and quality of life among youth residential care leavers: a longitudinal study

Journal of Child Psychology and Psychiatry, EarlyView.
Background Adults formerly placed out‐of‐home (care leavers) often accumulate multiple psychosocial adversities that can lead to poor quality of life (QoL) and place them at high risk for developing mental disorders persisting into adulthood. This study examines the development of mental disorders among care leavers and their QoL, differentiating by ...
Milou Leiting, Katharina Beck, Süheyla Seker, David Bürgin, Delfine d'Huart, Jörg M. Fegert, Nils Jenkel, Cyril Boonmann, Klaus Schmeck, Marc Schmid   +9 more
wiley   +1 more source

DHHC3 interferes with antitumor immunity in melanoma cells. [PDF]

Oncotarget
Sharma C, Hwang S, Liu Q, Hemler ME.
europepmc   +1 more source