Results 101 to 110 of about 102,493 (259)

The psychometric properties of validated tools to assess cannabis use disorder: A systematic review and meta‐analysis

open access: yesAddiction, EarlyView.
Abstract Aims To systematically review the evidence on the psychometric performance and accuracy of screening or diagnostic tools for cannabis use disorder. Method Systematic review and meta‐analysis which included studies conducted in clinical settings, schools, universities, community settings and population‐based surveys in multiple countries and ...
Janni Leung   +8 more
wiley   +1 more source

Impact of bariatric surgery on alcohol‐use disorder and alcohol‐related liver disease: A retrospective study

open access: yesAddiction, EarlyView.
Abstract Background and aims Increased risk of alcohol dependence is recognised following bariatric surgery. Modified gastrointestinal anatomy and neurohormonal profiles lead to altered alcohol metabolism, peak blood alcohol concentrations and enhanced reward circuits and cravings.
Thomas J. Williams   +4 more
wiley   +1 more source

Brain reward function in young people with cannabis use disorder: A functional magnetic resonance imaging study

open access: yesAddiction, EarlyView.
Abstract Background and Aims Cannabis use disorder (CUD) affects ~50 million people globally. Neuroscientific theories suggest that a blunted neural response to non‐drug rewards is a hallmark of substance use disorders; however, this remains untested in CUD. The current study tested whether brain reward system responses to the anticipation and feedback
Martine Skumlien   +15 more
wiley   +1 more source

Gambling disorder in late life: A systematic review of behavioral patterns, clinical correlates, and psychotherapeutic interventions

open access: yesThe American Journal on Addictions, EarlyView.
Abstract Background and Objectives Gambling in older adults represents an emerging but still underrecognized mental health concern. Although gambling participation is increasingly observed in later life, the specific psychological, social, cognitive, and biological factors associated with gambling‐related problems in older adults remain insufficiently ...
Graziella C. Prezzavento   +6 more
wiley   +1 more source

Mesenchymal Stem Cells From a Klinefelter Syndrome Patient: Functional Characterization and Therapeutic Implications

open access: yesAndrology, EarlyView.
ABSTRACT Background Cell therapy, particularly those utilizing mesenchymal stem/stromal cells (MSCs), is gaining traction as a therapeutic option for regenerative treatment in patients with limited therapeutic options. Although the safety of MSC‐based interventions is well established, uncertainties remain regarding how genetic abnormalities and ...
Marzena Zychowicz   +12 more
wiley   +1 more source

Predictors of treatment outcome for internet‐delivered cognitive‐behavioural therapy for individuals with obsessive‐compulsive disorder: A systematic review

open access: yesBritish Journal of Clinical Psychology, EarlyView.
Abstract Objectives Internet‐delivered cognitive‐behavioural therapy (ICBT) is demonstrated to be an effective treatment for obsessive‐compulsive disorder (OCD). However, not all individuals who commence ICBT respond well to treatment and thus understanding predictors of outcome is crucial for informing best‐practice treatment planning. The aim of this
Jun Hong Lee, Bethany M. Wootton
wiley   +1 more source

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

open access: yesBritish Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam   +3 more
wiley   +1 more source

Review: Paternal tobacco smoking and the risk of attention‐deficit hyperactivity disorder in children – a systematic review and meta‐analysis

open access: yesChild and Adolescent Mental Health, EarlyView.
Background Evidence on the association between paternal smoking and attention‐deficit hyperactivity disorder (ADHD) in offspring is inconsistent. We conducted a systematic review and meta‐analysis to synthesise the available evidence. Methods This meta‐analysis was performed following the Preferred Reporting Items for Systematic Review and Meta ...
Berihun Dachew   +3 more
wiley   +1 more source

Review: Memory bias in adolescents with depression – a systematic review and meta‐analysis

open access: yesChild and Adolescent Mental Health, EarlyView.
Background Memory bias, the tendency to retrieve specific memories, is an established phenomenon in adults with depression. However, evidence on the link between depression and memory bias in children is mixed. This systematic review aimed to synthesize current knowledge examining memory bias and depression in children and adolescents.
Anett Schumacher   +7 more
wiley   +1 more source

NRF2/xCT‐Mediated Antioxidant Adaptation Attenuates Apoptosis Induced by ASCT2 Inhibition in Prostate Cancer

open access: yesCancer Science, EarlyView.
ASCT2 inhibition induces ROS accumulation and activates NRF2‐dependent xCT upregulation in prostate cancer. This adaptive response partially supports residual cystine acquisition and glutathione synthesis, whereas combined ASCT2 and xCT inhibition disrupts redox compensation and predominantly promotes apoptotic cell death.
Jiaxing Wei   +9 more
wiley   +1 more source

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