Results 21 to 30 of about 194,910 (352)
Congenital Athymia: Unmet Needs and Practical Guidance
Therapeutics and Clinical Risk Management, 2023 Evey Howley,1 E Graham Davies,1 Alexandra Y Kreins1,2 1Department of Immunology and Gene Therapy, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; 2Infection, Immunity and Inflammation Research & Teaching Department, University
Howley E, Davies EG, Kreins AY
doaj
Immunological Emergency in Neonate: Case Report and Role of Early Screening
American Journal of Perinatology Reports, 2018 Healthy looking newborns may have severe combined immunodeficiency (SCID), and neonatologists frequently are the first physicians to encounter these patients.
Veronica Mugarab Samedi +3 more
doaj +1 more source
Induced Pluripotent Stem Cell Meets Severe Combined Immunodeficiency [PDF]
Cell Journal, 2020 Severe combined immunodeficiency (SCID) is classified as a primary immunodeficiency, which is characterized by impaired T-lymphocytes differentiation. IL2RG, IL7Ralpha, JAK3, ADA, RAG1/RAG2, and DCLE1C (Artemis) are the most defective genes in SCID.
Reza Kouchaki +6 more
doaj +1 more source
Disease Models & Mechanisms, 2019 Mutations in the gene AK2 are responsible for reticular dysgenesis (RD), a rare and severe form of primary immunodeficiency in children. RD patients have a severely shortened life expectancy and without treatment die, generally from sepsis soon after ...
Alberto Rissone +8 more
doaj +1 more source
Increased γ-H2A.X intensity in response to chronic medium-dose-rate γ-ray irradiation. [PDF]
PLoS ONE, 2012 BACKGROUND: The molecular mechanisms of DNA repair following chronic medium-dose-rate (MDR) γ-ray-induced damage remain largely unknown. METHODOLOGY/PRINCIPAL FINDINGS: We used a cell function imager to quantitatively measure the fluorescence intensity ...
Takashi Sugihara +2 more
doaj +1 more source
Adequate screening of youngsters for depressive characteristics [PDF]
, 2013 Introduction. In order to set up an effective early-detection of depressive symptoms in youngsters, the current study aims to investigate whether two measure moments of the Children's Depression Inventory (CDI) improve screening and whether a multi ...
Braet, Caroline +4 more
core +2 more sources
Blocking entry of hepatitis B and D viruses to hepatocytes as a novel immunotherapy for treating chronic infections [PDF]
, 2021 Background. Chronic hepatitis B and D virus (HBV/HDV) infections can cause cancer. Current HBV therapy using nucleoside analogues (NAs) is life-long and reduces but does not eliminate the risk of cancer.
Ahlén, G +13 more
core +1 more source
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Frontiers in Immunology, 2021 The implementation of severe combined immunodeficiency (SCID) newborn screening has played a pivotal role in identifying these patients early in life as well as detecting various milder forms of T cell lymphopenia (TCL).
Vasudha Mantravadi +8 more
doaj +1 more source
Cognitive behavioral group therapy versus psychoeducational intervention in Parkinson's disease [PDF]
, 2018 Objective: The aim of the current study was to evaluate whether cognitive behavioral group therapy has a positive impact on psychiatric, and motor and non-motor symptoms in Parkinson’s disease (PD).
Berardelli, Isabella +7 more
core +2 more sources