Reliability and clinical usefulness of the personality inventory for DSM-5 in clinically referred adolescents. A preliminary report in a sample of Italian inpatients [PDF]
Background The DSM-5 Alternative Model of Personality Disorders (AMPD) provides the opportunity to integrate the needed developmental perspective in the assessment of personality pathology. Based on this model, Krueger and colleagues (2012) developed the
Ardizzone, I +9 more
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Congenital Athymia: Unmet Needs and Practical Guidance
Evey Howley,1 E Graham Davies,1 Alexandra Y Kreins1,2 1Department of Immunology and Gene Therapy, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; 2Infection, Immunity and Inflammation Research & Teaching Department, University
Howley E, Davies EG, Kreins AY
doaj
Immunological Emergency in Neonate: Case Report and Role of Early Screening
Healthy looking newborns may have severe combined immunodeficiency (SCID), and neonatologists frequently are the first physicians to encounter these patients.
Veronica Mugarab Samedi +3 more
doaj +1 more source
Increased γ-H2A.X intensity in response to chronic medium-dose-rate γ-ray irradiation. [PDF]
BACKGROUND: The molecular mechanisms of DNA repair following chronic medium-dose-rate (MDR) γ-ray-induced damage remain largely unknown. METHODOLOGY/PRINCIPAL FINDINGS: We used a cell function imager to quantitatively measure the fluorescence intensity ...
Takashi Sugihara +2 more
doaj +1 more source
In Vivo Imaging of Transplanted Islets with ^(64)Cu-DO3A-VS-Cys^(40)-Exendin-4 by Targeting GLP-1 Receptor [PDF]
Glucagon-like peptide 1 receptor (GLP-1R) is highly expressed in pancreatic islets, especially on β-cells. Therefore, a properly labeled ligand that binds to GLP-1R could be used for in vivo pancreatic islet imaging.
Bading, James R. +11 more
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TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Regulated progression of B lymphocyte differentiation from cultured fetal liver. [PDF]
Lymphoid fetal liver cultures (LFLC) are long-term, nontransformed cultures of early B lymphoid lineage cells which appear developmentally blocked at the pre-B stage in vitro.
Denis, KA, Dorshkind, K, Witte, ON
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Severe combined immunodeficiency (SCID) comprises a heterogeneous group of inherited immunologic disorders with profound defects in cellular and humoral immunity. SCID is the most severe PID and constitutes a pediatric emergency.
Ibtihal Benhsaien +5 more
doaj +1 more source
The implementation of severe combined immunodeficiency (SCID) newborn screening has played a pivotal role in identifying these patients early in life as well as detecting various milder forms of T cell lymphopenia (TCL).
Vasudha Mantravadi +8 more
doaj +1 more source
Fludarabine as a cost-effective adjuvant to enhance engraftment of human normal and malignant hematopoiesis in immunodeficient mice [PDF]
There is still an unmet need for xenotransplantation models that efficiently recapitulate normal and malignant human hematopoiesis. Indeed, there are a number of strategies to generate humanized mice and specific protocols, including techniques to ...
A Rambaldi +17 more
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