Results 21 to 30 of about 192,238 (309)

A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress

Disease Models & Mechanisms, 2019
Mutations in the gene AK2 are responsible for reticular dysgenesis (RD), a rare and severe form of primary immunodeficiency in children. RD patients have a severely shortened life expectancy and without treatment die, generally from sepsis soon after ...
Alberto Rissone, Erin Jimenez, Kevin Bishop, Blake Carrington, Claire Slevin, Stephen M. Wincovitch, Raman Sood, Fabio Candotti, Shawn M. Burgess   +8 more
doaj   +1 more source

Fludarabine as a cost-effective adjuvant to enhance engraftment of human normal and malignant hematopoiesis in immunodeficient mice [PDF]

, 2018
There is still an unmet need for xenotransplantation models that efficiently recapitulate normal and malignant human hematopoiesis. Indeed, there are a number of strategies to generate humanized mice and specific protocols, including techniques to ...
A Rambaldi, A Terenzi, AM Carroll, AM Carroll, BS Andersson, CR Giver, D Niederwieser, DA Frank, DE Mosier, E McCormack, F Aversa, IF Khouri, K Tajima, L Luznik, L Weiss, M Furukawa, NC Kirkiles-Smith, S Goyama   +17 more
core   +1 more source

In Vivo Imaging of Transplanted Islets with ^(64)Cu-DO3A-VS-Cys^(40)-Exendin-4 by Targeting GLP-1 Receptor [PDF]

, 2011
Glucagon-like peptide 1 receptor (GLP-1R) is highly expressed in pancreatic islets, especially on β-cells. Therefore, a properly labeled ligand that binds to GLP-1R could be used for in vivo pancreatic islet imaging.
Bading, James R., Colcher, David, Conti, Peter E., Fraser, Scott E., Ishiyama, Kohei, Kandeel, Fouad, Li, Lin, Li, Zibo, Nair, Indu, Shively, John E., Todorov, Ivan, Wu, Zhanhong   +11 more
core   +2 more sources

Genetics of SCID

Italian Journal of Pediatrics, 2010
Human SCID (Severe Combined Immunodeficiency) is a prenatal disorder of T lymphocyte development, that depends on the expression of numerous genes.
Cossu Fausto
doaj   +1 more source

Severe Combined Immunodeficiency Disorder due to a Novel Mutation in Recombination Activation Gene 2: About 2 Cases

Case Reports in Immunology, 2021
Severe combined immunodeficiency (SCID) comprises a heterogeneous group of inherited immunologic disorders with profound defects in cellular and humoral immunity. SCID is the most severe PID and constitutes a pediatric emergency.
Ibtihal Benhsaien, Fatima Ailal, Khadija Elazhary, Jalila El bakkouri, Abdallah Badou, Ahmed Aziz Bousfiha   +5 more
doaj   +1 more source

Immunological Findings and Clinical Outcomes of Infants With Positive Newborn Screening for Severe Combined Immunodeficiency From a Tertiary Care Center in the U.S.

Frontiers in Immunology, 2021
The implementation of severe combined immunodeficiency (SCID) newborn screening has played a pivotal role in identifying these patients early in life as well as detecting various milder forms of T cell lymphopenia (TCL).
Vasudha Mantravadi, Jeffrey J. Bednarski, Michelle A. Ritter, Hongjie Gu, Ana L. Kolicheski, Caroline Horner, Megan A. Cooper, Maleewan Kitcharoensakkul, Maleewan Kitcharoensakkul   +8 more
doaj   +1 more source

Reliability and clinical usefulness of the personality inventory for DSM-5 in clinically referred adolescents. A preliminary report in a sample of Italian inpatients [PDF]

, 2016
Background The DSM-5 Alternative Model of Personality Disorders (AMPD) provides the opportunity to integrate the needed developmental perspective in the assessment of personality pathology. Based on this model, Krueger and colleagues (2012) developed the
Ardizzone, I, Borroni, S, Fantini, Fiorella, Ferrara, Mauro, Fossati, A, Krueger, Rf, Markon, Ke, Somma, A, Terrinoni, Arianna, Williams, Riccardo   +9 more
core   +1 more source

Newborn Screening for Severe Combined Immunodeficiency: Lessons Learned from Screening and Follow-Up of the Preterm Newborn Population

International Journal of Neonatal Screening, 2023
Newborn screening (NBS) for Severe Combined Immunodeficiency (SCID) by measurement of T-cell receptor excision circles (TRECs) successfully identifies newborns with SCID and severe T-cell lymphopenia, as intended.
Amy Gaviglio, Michael Lasarev, Ruthanne Sheller, Sikha Singh, Mei Baker   +4 more
doaj   +1 more source

Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum. [PDF]

, 2018
BACKGROUND: The study of Onchocerca volvulus has been limited by its host range, with only humans and non-human primates shown to be susceptible to the full life cycle infection.
Abraham, David, Bennuru, Sasisekhar, Eberhard, Mark L., Hess Ligas, Jessica A., Lustigman, Sara, Nutman, Thomas B., Patton, John B., Torigian, April R.   +7 more
core   +3 more sources

FcγRII (CD32) modulates antibody clearance in NOD SCID mice leading to impaired antibody-mediated tumor cell deletion

Journal for ImmunoTherapy of Cancer, 2020
Background Immune compromised mice are increasingly used for the preclinical development of monoclonal antibodies (mAb). Most common are non-obese diabetic (NOD) severe combined immunodeficient (SCID) and their derivatives such as NOD SCID interleukin-2 ...
Robert J Oldham, C Ian Mockridge, Sonya James, Patrick J Duriez, H T Claude Chan, Kerry L Cox, Vicentiu A Pitic, Mark S Cragg   +7 more
doaj   +1 more source