Results 51 to 60 of about 192,238 (309)

RAG-1 Mutations Associated with B-Cell-Negative SCID Dissociate the Nicking and Transesterification Steps of V(D)J Recombination [PDF]

, 2001
Some patients with B-cell-negative severe combined immune deficiency (SCID) carry mutations in RAG-1 or RAG-2 that impair V(D)J recombination. Two recessive RAG-1 mutations responsible for B-cell-negative SCID, R621H and E719K, impair V(D)J recombination
Chang, Fu-Chung, Desiderio, Stephen, Li, Wenhui   +2 more
core   +2 more sources

XBP1s Mediates Cross‐resistance to Combination Treatment of CDK4/6 Inhibitors plus Endocrine Therapy in Breast Cancer

Advanced Science, EarlyView.
Elevated spliced form of X‐box–binding protein 1 (XBP1) correlates with unfavorable responses to endocrine therapy plus CDK4/6 inhibitors in HR+/HER2− advanced breast cancer. XBP1s facilitates cell proliferation and G1/S transition by transcriptionally activating SND1, thereby activating the E2F1 pathway.
Yuting Sang, Shiyang Liu, Xujie Zhou, Weiru Chi, Min Xiong, Ming Chen, Hengyu Ren, Douwaner Liu, Liyi Zhang, Jingyan Xue, Yayun Chi, Jiong Wu   +11 more
wiley   +1 more source

Multiplex HDR for disease and correction modeling of SCID by CRISPR genome editing in human HSPCs

Molecular Therapy: Nucleic Acids, 2023
Severe combined immunodeficiency (SCID) is a group of disorders caused by mutations in genes involved in the process of lymphocyte maturation and function.
Ortal Iancu, Daniel Allen, Orli Knop, Yonathan Zehavi, Dor Breier, Adaya Arbiv, Atar Lev, Yu Nee Lee, Katia Beider, Arnon Nagler, Raz Somech, Ayal Hendel   +11 more
doaj   +1 more source

Treponema denticola in Disseminating Endodontic Infections [PDF]

, 2006
Treponema denticola is a consensus periodontal pathogen that has recently been associated with endodontic pathology. In this study, the effect of mono-infection of the dental pulp with T.
Foschi, F., Izard, Jacques, Müller, R., Prati, C., Sambri, V., Sasaki, H., Stashenko, P.   +6 more
core   +2 more sources

Spontaneous Expression of Interleukin-2 In Vivo in Specific Tissues of Young Mice [PDF]

, 1998
In situ hybridization and immunohistochemistry were used to determine the spectrum of tissues in which interleukin-2 (IL-2) mRNA and protein are found in healthy, normal young mice.
Rothenberg, Ellen V., Yang-Snyder, Julia A.   +1 more
core   +4 more sources

Blocking entry of hepatitis B and D viruses to hepatocytes as a novel immunotherapy for treating chronic infections [PDF]

, 2021
Background. Chronic hepatitis B and D virus (HBV/HDV) infections can cause cancer. Current HBV therapy using nucleoside analogues (NAs) is life-long and reduces but does not eliminate the risk of cancer.
Ahlén, G, Frelin, L, Jagya, N, Johansson, M, Maravelia, P, Meuleman, Philip, Ni, Y, Pasetto, A, Pater, L, Pérez, NC, Sällberg, M, Urban, S, Verch, G, Verhoye, Lieven   +13 more
core   +1 more source

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

A Cost-Effectiveness Analysis of Newborn Screening for Severe Combined Immunodeficiency in the UK

International Journal of Neonatal Screening, 2019
Severe combined immunodeficiency (SCID) can be detected through newborn bloodspot screening. In the UK, the National Screening Committee (NSC) requires screening programmes to be cost-effective at standard UK thresholds.
Alice Bessey, James Chilcott, Joanna Leaviss, Carmen de la Cruz, Ruth Wong   +4 more
doaj   +1 more source

CD3ε+ Cells in Pigs With Severe Combined Immunodeficiency Due to Defects in ARTEMIS

Frontiers in Immunology, 2020
Severe combined immunodeficiency (SCID) is described as the lack of functional T and B cells. In some cases, mutant genes encoding proteins involved in the process of VDJ recombination retain partial activity and are classified as hypomorphs. Hypomorphic
Adeline N. Boettcher, A. Giselle Cino-Ozuna, Yash Solanki, Jayne E. Wiarda, Jayne E. Wiarda, Jayne E. Wiarda, Ellie Putz, Jeana L. Owens, Sara A. Crane, Amanda P. Ahrens, Crystal L. Loving, Joan. E. Cunnick, Raymond R. R. Rowland, Sara E. Charley, Jack C. M. Dekkers, Christopher K. Tuggle   +15 more
doaj   +1 more source

Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models [PDF]

, 2010
Chimpanzees represent the only animal model for studies of the natural history of hepatitis C virus (HCV). To generate virus stocks of important HCV variants, we infected chimpanzees with HCV strains of genotypes 1-6 and determined the infectivity titer ...
Bukh, Jens, Eder, Gerald, Engle, Ronald E, Feinstone, Stephen M, Govindarajan, Sugantha, Krawczynski, Krzysztof, Leroux-Roels, Geert, Meuleman, Philip, Miller, Roger H, Purcell, Robert H, Satterfield, William C, Tellier, Raymond   +11 more
core   +1 more source