Results 71 to 80 of about 102,493 (259)

A Case of T- B- NK+ SCID Without an Identifiable SCID Mutation

Journal of Human Immunity
IntroductionThe T cell receptor excision circle (TREC) assay is an effective neonatal screening tool for severe combined immunodeficiency (SCID), enabling early diagnosis and timely intervention.
Doreen Khakshour, Vincent Bonagura
doaj   +1 more source

Generation and Characterization of Severe Combined Immunodeficiency Rats

Cell Reports, 2012
Severe combined immunodeficiency (SCID) mice, the most widely used animal model of DNA-PKcs (Prkdc) deficiency, have contributed enormously to our understanding of immunodeficiency, lymphocyte development, and DNA-repair mechanisms, and they are ideal ...
Tomoji Mashimo, Akiko Takizawa, Junya Kobayashi, Yayoi Kunihiro, Kazuto Yoshimi, Saeko Ishida, Koji Tanabe, Ami Yanagi, Asato Tachibana, Jun Hirose, Jun-ichiro Yomoda, Shiho Morimoto, Takashi Kuramoto, Birger Voigt, Takeshi Watanabe, Hiroshi Hiai, Chise Tateno, Kenshi Komatsu, Tadao Serikawa   +18 more
doaj   +1 more source

Analysis of energy expenditure and behavioral characteristics in different mouse strains under normal and disease conditions

Animal Models and Experimental Medicine, EarlyView.
Mouse metabolic and behavioral phenotypes are tightly linked to strain, age and disease state, with distinct dysregulation in each disease model, underscoring the need for standardized preclinical experimental conditions. Abstract Background Metabolic and behavioral traits in mice exhibit substantial variability across strains, ages, and disease states,
Jiacheng Zeng, Yuanjun Ji, Yan Zou, Jing Tan, Teng Wu, Conghui Shen, Tongsheng Huang, Shijie Xiong, Mengying Liu, Maoquan Yang, Jingwei Lai, Jiangwei Ma, Junhong Wan, Xinlu Fu, Jiang Qian, Hui Li, Ludong Yuan, Weibin Cai   +17 more
wiley   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Gene Therapy As A Treatment Modality For Severe Combined Immunodeficiency : A Narrative Review

High Yield Medical Reviews
Introduction: Severe combined immunodeficiency (SCID) is a life-threatening genetic disorder marked by severe T-cell defects and often B-cell and NK-cell dysfunction, leading to an increased risk of infections.
Namareq Al-Mse'adeen, Ayham Al Mse'adeen
doaj   +1 more source

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source

Safe and Sound: Is Safeness a Specific Affective Dimension Related to Eating Disorder Behaviors?

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Safeness is a warm, soothing emotional state that is often experienced in the presence of close others. Safeness is thought to be distinct from other positive emotions or the absence of negative emotions and is shown to predict mental health variables over and above other emotions.
Ege Bicaker, Alexia E. Miller, Vittoria Trolio, Sarah E. Racine   +3 more
wiley   +1 more source

Dietetic‐Led Cognitive‐Behavioral Therapy for Avoidant/Restrictive Food Intake Disorder: Feasibility, Acceptability, and Proof‐of‐Concept

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Cognitive‐Behavioral Therapy for Avoidant/Restrictive Food Intake Disorder (CBT‐AR) is an emerging treatment for ARFID, but to date, it has only been delivered by mental health clinicians. Given the relevance of nutrition to treatment goals, we adapted the treatment to be dietetic‐led (D‐CBT‐AR).
Copeland G. Winten, Esben Strodl, Gabriella Heruc, Joanne Avery, Kamryn T. Eddy, Lynda J. Ross, Jennifer J. Thomas   +6 more
wiley   +1 more source

Development of a novel rodent model for dog heartworm microfilaremia using the severe-combined immunodeficiency mouse

Scientific Reports
Dirofilaria immitis is a mosquito-borne parasitic nematode that causes fatal heartworm disease in canids. The microfilariae are essential for research, including drug screening and mosquito-parasite interactions.
Mihoko Mizuseki, Nao Ikeda, Takahiro Shirozu, Maki Yamagishi, Sugao Oshiro, Shinya Fukumoto   +5 more
doaj   +1 more source