Results 41 to 50 of about 4,214,970 (307)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

What's the use of basic science? [PDF]

open access: yes, 1997
With public expenditure under pressure, the criteria for the allocation of funding to scientific research have come under increasing scrutiny. It is sometimes asserted that funds should be focused on applied (ÒusefulÓ) science and technology, rather than
Llewellyn Smith, Christopher Hubert
core  

Evolution of Axial-Field Electrical Machines

open access: yesSultan Qaboos University Journal for Science, 2000
This paper is a review of axial-field electrical machines, which were at the origin of the invention of electrical machines such as the famous Faraday’s disk.
Abdullah Al-Badi   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Computational Visualistics: Dealing with Pictures in Computer Science [PDF]

open access: yes, 2005
Building blocks from many disciplines have to be integrated into a general science of images. Computational visualistics has been formed as a contributing field embracing all aspects of dealing with images computationally.
Schirra, Dr Jörg R.J.
core  

Calibration of Transit Operations Planning (TOP) Model and Evaluation of Bus Transit Route Performance in Riyadh

open access: yesSultan Qaboos University Journal for Science, 1997
Public transit systems provide mobility for a large percentage of urban residents very cost-effectively and with minimum negative impact on the environment.
P.A. Koushki, G.A. Ali, Y.A. Al-Nuaim
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Esteban Terradas and Spanish technoscientific modernity [PDF]

open access: yes, 2004
Science, technology and technoscience We live in an age in which science and technology play such important roles in the lives of individuals and nations that they figure among the most important affairs of any nation. And although many persist in seeing
Sánchez Ron, José Manuel
core  

Mycoflora and Mycotoxigenic Moulds of Pistachio Nuts for Human Consumption in the Sultanate of Oman

open access: yesSultan Qaboos University Journal for Science, 1998
Mycoflora of 75 cans of different batches and brands of pistachio nuts purchased in the Sultanate of Oman was studied. A number of fungi were isolated, with percentages of contaminated nuts [average between brands ] as follows: Aspergillus niger 14.8 ...
A. E. Elshafie, N. S. AL-Shally
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

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