Results 61 to 70 of about 35,698,712 (297)

On the Excitation of Instability Waves in Plane Poisuille Flow by a Concentrated Source at the Wall

Sultan Qaboos University Journal for Science, 1999
The paper addresses the excitation of instability waves in plane Poiseuille flow by means of a concentrated source at the wall. The aim of this paper is to investigate the relation between the source amplitude and the excited wave amplitude for  various ...
Ayman Al-Maaitah
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Tailings From Mining Activities, Impact on Groundwater, and Remediation

Sultan Qaboos University Journal for Science, 2001
Effluent wastes from mining operations and beneficiation processes are comprized mostly of the following pollutants: total suspended solids (TTS), alkalinity or acidity (pH), settleable solids, iron in ferrous mining, and dissolved metals in nonferrous ...
Khalid Al-Rawahy
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Modeling Flow and Transport in Unsaturated Porous Media: A Review

Sultan Qaboos University Journal for Science, 2000
Underground water is a vital natural resource and every effort should be made to understand ways and means of efficiently using and managing it. The unsaturated zone, bounded at its top by the land surface and below by the water table, is the region ...
H.H. Al-Barwani, M. Al-Lawatia, E. Balakrishnan, A. Purnama   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Constructing Node-Disjoint Routes in K-Ary N-Cubes

Sultan Qaboos University Journal for Science, 1997
In this paper, a method for constructing node-disjoint (parallel) paths in k-ary n-cube interconnection networks is described. We start by showing in general how to construct parallel paths in any Cartesian product of two graphs based on known paths in ...
Khaled Day, Abdel Elah Al-Ayyoub
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Filter Representation of Normal Lattice

Sultan Qaboos University Journal for Science, 1996
In this paper we will investigate the properties of normality lattices and their relationships to zero-one measures. We will establish necessary and sufficient conditions for lattices to be normal.
B. Yallaoui
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source