Results 71 to 80 of about 2,408,246 (297)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Can Democracy Survive AI?

open access: yesSociologica
This essay examines the fundamental tension between artificial intelligence technologies and democratic governance, arguing that AI’s inherent tendencies toward centralization and control pose significant challenges to democratic societies.
Gina Neff
doaj   +1 more source

Science, technology, and society studies

open access: yes, 2018
This entry examines contemporary scholarship on media and information technologies at the intersection of science and technology studies (STS) and communication studies. The term “media and information technologies” is used to bring together a variety of research frameworks that seek to capture symbolic, social, cultural, or political aspects of ...
Siles González, Ignacio   +3 more
openaire   +3 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Using 3 Dimension Health Vegetation Index Point Clouds to Determine HLB Infected Citrus Trees

open access: yesJournal of Aviation/Aerospace Education & Research, 2018
Three-dimensional NDVI point clouds can be an innovative method for detecting Huanglongbing (HLB) disease in citrus trees. In February 2018, an Unmanned Aircraft System (UAS) captured narrow-band multispectral images to detect healthiness variations of ...
Joseph Cerreta   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Debugging the Techno-Utopian Myth of Predictive Policing

open access: yesJournal of Extreme Anthropology, 2021
Kira Vrist Rønn
doaj   +1 more source

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