Results 71 to 80 of about 2,250,027 (306)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
International Journal of Communication, 2019 In this article, we propose a new theoretical premise called the “carrier wave principle.” It holds that there is no fixed limit to the amount and variety of knowledge that may be produced from a given cultural artifact.
Aram Sinnreich, Jesse Gilbert
doaj
Recherche en histoire de l’acoustique moderne
Revue d'anthropologie des connaissances, 2019 In this article, Viktoria Tkaczyk, who leads the research team Epistemes of Modern Acoustics at the Max Plank Institute in Berlin, discusses the ongoing works, the research perspectives and the “sound” turn within history of sciences.
Viktoria Tkaczyk, François Ribac
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The 'Matters' of Science Diplomacy: Transversal Analysis of the S4D4C Case Studies [PDF]
, 2020 What matters in science diplomacy? That is the question that the publication of the S4D4C project (see www.s4d4c.eu) “The 'Matters' of Science Diplomacy: Transversal Analysis of the S4D4C Case Studies” aims to answer.
Melchor, Lorenzo +13 more
core +1 more source
Science, technology, and society studies
, 2018 This entry examines contemporary scholarship on media and information technologies at the intersection of science and technology studies (STS) and communication studies. The term “media and information technologies” is used to bring together a variety of research frameworks that seek to capture symbolic, social, cultural, or political aspects of ...
Siles González, Ignacio +3 more
openaire +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source