Results 61 to 70 of about 2,250,027 (306)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Meta-Governance for Science Diplomacy - towards a European framework [PDF]

open access: yes, 2019
More and more foreign policy organisations become imbued with the promises Science Diplomacy might hold. It may transform or at least reframe the mobilization of knowledge in and for international scientific as well as political relations, not least to ...
Kuhlmann, Stefan   +4 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

CWTS Leiden Ranking 2018

open access: yes
This data set provides the statistics made available in the 2018 edition of the CWTS Leiden Ranking.
Centre for Science and Technology Studies
core   +1 more source

Museos, artefactos y sociedad: ¿Cómo se configura su dimensión educativa?

open access: yesUniversitas Humanística, 2013
This article presents a theoretical and methodological approach to identify the educational dimension present in socio-technical systems. It specifically explores how this dimension is configured in the conceptualization, building and appropriation ...
Manuel Franco-Avellaneda
doaj  

Research in the history of modern acoustics

open access: yesRevue d'anthropologie des connaissances, 2019
In this article, Viktoria Tkaczyk, who leads the research team Epistemes of Modern Acoustics at the Max Plank Institute in Berlin, discusses the ongoing works, the research perspectives and the “sound” turn within history of sciences.
Viktoria Tkaczyk, François Ribac
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

CWTS Leiden Ranking 2017

open access: yes
This data set provides the statistics made available in the 2017 edition of the CWTS Leiden Ranking.
Centre for Science and Technology Studies
core   +1 more source

De-Facto Science Policy in the Making: How Scientists Shape Science Policy and Why it Matters (or, Why STS and STP Scholars Should Socialize)

open access: yes, 2013
Science and technology (S&T) policy studies has explored the relationship between the structure of scientific research and the attainment of desired outcomes.
Miller, Thaddeus R.   +3 more
core   +1 more source

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