Results 131 to 140 of about 19,035,900 (253)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Correction: Comparative Evaluation of Therapeutic Effects of Boric Acid and Triamcinolone in Nasal Polyp Culture. [PDF]

Biol Trace Elem Res
Türe N, Gündüz MK, Kaymak G, Sezgin AK, Varol M.   +4 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Insights on the effect of extracellular acidification on an HCN channel: A molecular dynamics study. [PDF]

PLoS One
Asgharpour S, Lazaratos M, Spehr M, Carloni P.   +3 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

SOCIAL SCIENCES COMPETENCES FOR PRIMARY SCHOOL TEACHER’S QUALIFICATIONS

Didáctica Geográfica
The purpose of the present article is to think about state of question and critical analysis of social sciences, for the new Title of Degree of Teacher in Primary Education.
Clemente Herrero Fabregat, María Montserrat Pastor Blázquez   +1 more
doaj  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Research-creation in the health sciences: A scoping review protocol. [PDF]

PLoS One
Ha CJ, Fawaz NV, Dennett L, Armijo-Olivo S, Barlott T, Peers D.   +5 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Author Correction: Generation and characterization of neutralizing antibodies against M1R and B6R proteins of monkeypox virus. [PDF]

Nat Commun
Qu Y, Tai W, Ma E, Jiang Q, Fan M, Xiao W, Tian C, Liu Y, Liu J, Wang X, Ge J, Cheng G.   +11 more
europepmc   +1 more source