Results 81 to 90 of about 9,825,591 (304)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Интегральная индивидуальность как научная теория

Научно-педагогическое обозрение
Впервые подвергается анализу интегральная индивидуальность как научная теория, которую создал В.С. Мерлин. Он показал, что существует множество разнородных по происхождению индивидуальных свойств.
Дорфман Леонид Яковлевич
doaj   +1 more source

Acknowledgement to reviewers [PDF]

Journal of Interdisciplinary Sciences, 2018
The Journal of Interdisciplinary Sciences (JIS) wishes to thank all the reviewers for their intellectual contributions by timely reviewing manuscripts, and supporting the journal’s vision of “Enriching Beautiful Minds towards Intelligent Minds”.
Editor-in-Chief
doaj  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

ВІДРЯДЖЕННЯ УКРАЇНСЬКИХ УЧЕНИХ ЯК ВАЖЛИВА СКЛАДОВА МІЖНАРОДНИХ НАУКОВИХ ЗВ’ЯЗКІВ у другій половині ХІХ — на початку ХХ ст. (на прикладі вишів Наддніпрянщини) [PDF]

Storìnki Istorìï, 2013
One of the most essential ways of learning and knowledge exchange between scientists from different countries are academic study tours. The purpose of this article is to analyze features of foreign academic trips during the 19th – early 20th cent ...
С. М. Ховрич
doaj  

Scientific misconduct and correcting the scientific literature

Academic Medicine, 1999
Journal editors are among those who must face the issue of when and how to correct the scientific literature when an allegation or finding of scientific misconduct occurs. The author describes an instructive incident of tainted data and a subsequent allegation of misconduct that involved a federally-sponsored study where some data had been fabricated ...
openaire   +3 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Editorial [PDF]

Journal of Interdisciplinary Sciences
Dear Readers, We are again thrilled to announce our current publication of Volume 8, Issue 1- May 2024. Within the academic and scientific journey of consistency publication have gained multiple experiences with the authors and reviewers, which the ...
Mani man Singh Rajbhandari
doaj  

Research governance and scientific knowledge production in The Gambia

South African Journal of Science, 2014
Public research institutions and scientists are principal actors in the production and transfer of scientific knowledge, technologies and innovations for application in industry as well for social and economic development.
Frederick U. Ozor
doaj   +1 more source