Results 71 to 80 of about 4,109,881 (267)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Editorial [PDF]

open access: yesJournal of Interdisciplinary Sciences
Dear Readers, It is our immense pleasure to announce that the Journal of Interdisciplinary Sciences (JIS) is now indexed in the DOAJ: Directory of Open Access Journals.
Mani Man Singh Rajbhandari
doaj  

Non-invasive Electrophysiological Characterization of Distinctive Meditative States in a Yogi during Samaadhi

open access: yesInternational Journal of Yoga
Although mechanistic studies on Yoga and meditation have demonstrated their efficacy over the past few decades, very few studies have focused on the Yogic state of Samaadhi, characterized by an ultimate state of peace and happiness.
D. Narayana Dutt   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Assessment and justification of directions for improving the efficiency of regional scientific, technological and innovation policy

open access: yesπ-Economy
The current stage of development of the Russian economy is characterized by the priority of achieving technological sovereignty. An important role in addressing this challenge is assigned to the regional level, which brings to the fore a set of issues ...
Nikolaev Mihail, Makhotaeva Marina
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

PEMBELAJARAN KREATIF BERBASIS LITERASI BAHASA MENUMBUHKAN ANAK YANG CERDAS DAN KREATIF

open access: yesINSANIA: Jurnal Pemikiran Alternatif Kependidikan, 2018
: This article discusses the scientific creative learning process based on language literacy. The purpose of this article is to describe how scientific-based creative learning based on language literacy can develop intelligent and creative children so ...
Umi Khomsiyatun
doaj   +1 more source

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