Results 141 to 150 of about 3,852,365 (305)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The graffiti artist : doing the work of the lyric through juxtaposition of disparate social discourse : a thesis presented in partial fulfilment of the requirements for Master of Creative Writing, Massey University, Manawatu, New Zealand [PDF]

, 2016
One way the lyric has developed over the last century is to accommodate non-poetic social discourses, e.g. languages of prose, genre, profession and cultural groups into the lyric tradition.
Ingram, Gail
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Thank you for your critical comments and helpful suggestions

Ibérica, 2001
Peer reviews of research papers submitted to journals are an "occluded" genre (Swales, 1996) - referees are usually anonymous and the confidential reports themselves are not part of the official record of research publication.
Hugh Gosden
doaj  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

The Conventionalization of the Passive in Late Modern Scientific English [PDF]

, 2008
[Abstract] This paper is part of a larger project in which I seek to find out the reasons behind the radical decrease in the use of passives in Present-day English scientific discourse.
Seoane, Elena
core  

Geographical component of the chronotope of the English scientific discourse and the forms of its representation

Вестник Самарского университета: История, педагогика, филология
The article deals with the geographical component of the chronotope of the English scientific discourse. The authors identify the forms of geographical representation of the chronotope of scientific discourse, determine the degree of identifiability of ...
S. A. Tserkovnov, K. B. Svoikin
doaj   +1 more source

Learned discourses: Timely scientific opinions [PDF]

Integrated Environmental Assessment and Management, 2007
openaire   +4 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Scientific Social Objects: The Social Objects and Multidimensional Network of the myExperiment Website

Scientific research is increasingly conducted digitally and online, and consequently we are seeing the emergence of new digital objects shared as part of the conduct and discourse of science.
Bechhofer, Sean, De Roure, David, Goble, Carole, Newman, David   +3 more
core