Results 141 to 150 of about 17,660,936 (332)

The landmarks of control and licensing system development for medicinal products in Russia (25 years since the establishment of the first state institution for expert evaluation of medicinal products)

open access: yesРегуляторные исследования и экспертиза лекарственных средств, 2018
The article describes the landmarks of control and licensing system development for the purpose of drug evaluation, marketing authorization and circulation in Russia. The need for the development of a state institution for performing expert evaluation of
V. K. Lepakhin   +6 more
doaj  

The use and misuse of the "impact factor" as a parameter for evaluation of scientific publication quality: a proposal to rationalize its application [PDF]

open access: gold, 2003
Paulo Marcos Zech Coelho   +5 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Review of methodological approaches to quality evaluation of recombinant interferon products

open access: yesБиопрепараты: Профилактика, диагностика, лечение, 2018
The article summarises methods used to control the quality of recombinant interferon alpha and beta (IFNs) products. It demonstrates that currently used methodological approaches generally ensure proper quality control of this group of medicines. However,
O. B. Ustinnikova   +6 more
doaj  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Analysis of the demand for reference standards used in quality evaluation of biologicals

open access: yesБиопрепараты: Профилактика, диагностика, лечение, 2018
Quality evaluation of biologicals entails some specific considerations and problems associated with inherent variability of biological systems. This has implications not only for biological and immunological test methods, but for physical and physico ...
V. I. Klimov   +6 more
doaj  

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