Results 131 to 140 of about 1,256,119 (263)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Playerload™ and accelerometer-based metrics: scientific evaluation and implications for athlete monitoring. [PDF]

Front Sports Act Living
Staunton CA, Edholm P, Ide BN, Ditroilo M, Wundersitz D.   +4 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Rethinking AI Workflows: Guidelines for Scientific Evaluation in Digital Health Companies. [PDF]

JMIR AI
McAlister KL, Gonzales L, Huberty J.
europepmc   +1 more source

Scientific Evaluation of Medicinal Plants Used for the Treatment of Cervicitis (Qorohe- Rahem) in Iranian Traditional Medicine. [PDF]

Iran J Pharm Res, 2019
Nabimeybodi R, Zareshahi R, Tansaz M, Vahid Dastjerdi M, Hajimehdipoor H.   +4 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Recommended approaches to the scientific evaluation of ecotoxicological hazards and risks of endocrine-active substances. [PDF]

Integr Environ Assess Manag, 2017
Matthiessen P, Ankley GT, Biever RC, Bjerregaard P, Borgert C, Brugger K, Blankinship A, Chambers J, Coady KK, Constantine L, Dang Z, Denslow ND, Dreier DA, Dungey S, Gray LE, Gross M, Guiney PD, Hecker M, Holbech H, Iguchi T, Kadlec S, Karouna-Renier NK, Katsiadaki I, Kawashima Y, Kloas W, Krueger H, Kumar A, Lagadic L, Leopold A, Levine SL, Maack G, Marty S, Meador J, Mihaich E, Odum J, Ortego L, Parrott J, Pickford D, Roberts M, Schaefers C, Schwarz T, Solomon K, Verslycke T, Weltje L, Wheeler JR, Williams M, Wolf JC, Yamazaki K.   +47 more
europepmc   +1 more source

Ewha Medical Journal passed the scientific evaluation by PubMed Central and succeeded in being included in DOAJ, but failed to be accepted by Scopus. [PDF]

Ewha Med J
Huh S.
europepmc   +1 more source

Integrated Care for People with Dementia-Results of a Social-Scientific Evaluation of an Established Dementia Care Model. [PDF]

Geriatrics (Basel), 2016
Richter S.
europepmc   +1 more source