Results 141 to 150 of about 1,477,560 (316)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 2014 The present study aimed to investigate the effect of the language of instruction on the participants’ acquisition of the scientific terms with respect to their knowledge, usage, proficiency, adoption and evaluation in two Arab universities.
Al-Asal, Mahmoud Sabri, Smadi, Oqlah
core +1 more source
Sampling in modern pharmaceutical analysis
Регуляторные исследования и экспертиза лекарственных средств, 2018 Sampling procedure is an integral part of the drug quality control system. Objective science-based sampling is an important operation when only a small amount of a material is taken and it is representative for the analysis of the whole product batch ...
T. N. Bokovikova +6 more
doaj
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Teachers’ experiences of teaching ‘ideas-about-science’ and socio-scientific issues
, 2007 Teaching of socio-scientific issues encourages a focus on ‘ideas-about-science’ (the processes and practices of science) and consideration of scientific evidence and values.
Hanley, Pam +2 more
core
Using Abductive Research Logic to Construct a Rigorous Explanation of Amorphous Evaluation Findings
, 2009 Background: Two kinds of research logic prevail in scientific research: deductive research logic and inductive research logic. However, both fail in the field of evaluation, especially evaluation conducted in unfamiliar environments.
Miri Levin-Rozalis, Levin-Rozalis, Miri
core +1 more source
On improving the safety of new direct acting oral anticoagulants
Безопасность и риск фармакотерапии, 2018 One of the main causes of death and disability in the world are the thrombotic complications. Using of anticoagulants is the effective method of preventing of these life-threatening conditions.
N. Yu. Velts +6 more
doaj
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Scientific Evaluation of the Court Evidence Submitted to the 2019 Human Papillomavirus Vaccine Libel Case and Its Decision in Japan. [PDF]
Front Med (Lausanne), 2020 Bodily JM, Tsunoda I, Alexander JS.
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source