Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Modern biological/biotechnological medicinal products. Topical issues and prospects for development
Биопрепараты: Профилактика, диагностика, лечение, 2018 The review provides with the information, related to the development, research and registration of new biological preparations, including the issues of terminology and classification.
Yu. V. Olefir +6 more
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Breast Reconstruction: Necessity for Further Standardization of the Current Surgical Techniques Attempting to Facilitate Scientific Evaluation and Select Tailored Individualized Procedures Optimizing Patient Satisfaction. [PDF]
Breast Care (Basel), 2021 Tampaki EC, Tampakis A.
europepmc +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
[Advertising or information in ophthalmology? : Scientific evaluation of a YouTube sample]. [PDF]
Ophthalmologe, 2021 Schrenk K +6 more
europepmc +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Evaluation of Scientific Research Assignments with Multidimensional Rasch Measurement Model
, 2010 The purpose of this study is to investigate the usefulness of the many-facet Rasch model (MFRM) in evaluating the quality of performance related to preparing Research assignment in higher education.
Basturk, R
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Peer review for the evaluation of the academic research: the Italian experience [PDF]
Peer review, that is the evaluation process based on judgments formulated by independent experts, is generally used for different goals: the allocation of research funding, the review of the research results submitted for publication in scientific ...
Anna Barbara +2 more
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Methodological approaches to the choice of identification test methods for medicines
Регуляторные исследования и экспертиза лекарственных средств, 2018 The article summarises the main selective and non-selective methods of physical, chemical and physico-chemical analysis which are used in medicines identification testing and which differ in selectivity, sensitivity, informative value, sample preparation,
A. I. Lutseva +10 more
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