Results 101 to 110 of about 11,994,000 (257)
Scientific evaluation of alleged findings in HPV vaccines: Molecular mimicry and mouse models of vaccine-induced disease. [PDF]
Cancer Sci, 2022 Matsumura N, Tsunoda I.
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 2020 The Clean Energy Transition—the pathway for decarbonizing global energy—is essential to foster inclusive and sustainable growth while addressing climate change.
Independent Evaluation Group
core +1 more source
Ketoacidosis as unexpected adverse reaction SGLT2 inhibitor
Безопасность и риск фармакотерапии, 2018 Inhibitors of the sodium-glucose cotransporter-2 SGLT2 is a new class of hypoglycemic drugs. This article presents the information on FDA reports (2013-2015) and AIS (May 2015 - February 2016) on the risk of new adverse reaction - ketoacidosis ...
T. M. Bukatina +7 more
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Cell cultures in replacement therapy
Биопрепараты: Профилактика, диагностика, лечение, 2018 Cell replacement therapy is one of the top priority areas of modern medicine, which is aimed at restoring the structure and functions of damaged tissues by transplanting cells grown in vitro .
E. M. Petruchuk +7 more
doaj
Breast Reconstruction: Necessity for Further Standardization of the Current Surgical Techniques Attempting to Facilitate Scientific Evaluation and Select Tailored Individualized Procedures Optimizing Patient Satisfaction. [PDF]
Breast Care (Basel), 2021 Tampaki EC, Tampakis A.
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
First available biosimilar monoclonal antibodies
Биопрепараты: Профилактика, диагностика, лечение, 2018 The review deals with the issues related to the special aspects of the development of the first available similar biopharmaceuticals/biological analogues («biosimilars») based on monoclonal antibodies.
Zh. I. Avdeeva +7 more
doaj
[Advertising or information in ophthalmology? : Scientific evaluation of a YouTube sample]. [PDF]
Ophthalmologe, 2021 Schrenk K +6 more
europepmc +1 more source