Results 91 to 100 of about 11,994,000 (257)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Guidance on Evaluation Inception Reports

open access: yes, 2023
This document provides guidance on how to develop an evaluation Inception Report and its core contents, namely the evaluation purpose, focus, design and ...
CGIAR Independent Evaluation Arrangement
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

An Evaluation of World Bank Investment Climate Activities

open access: yes, 2004
The Investment Climate Study is a evaluation of the Operations Evaluation Department (OED). The OED report reviews the Bank’s investment climate lending and non-lending activities during fiscal years 1993 through
Operations Evaluation Department
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Report of the IEA Workshop on Evaluating the Quality of Science, Rome, 10-11 December 2015

open access: yes, 2020
IEA organized a 1.5 day (10-11 December 2015) internal workshop to discuss approaches and experiences in assessing science quality, primarily through evaluations in the CGIAR.
CGIAR Independent Evaluation Arrangement
core  

Determination of visible particles in parenteral dosage forms and ophthalmic dosage forms

open access: yesРегуляторные исследования и экспертиза лекарственных средств, 2018
The present article describes the approaches to the choice of methods for assessing the content of visible particles in parenteral and ophthalmic dosage forms, recognized in general pharmacopoeia monograph «Visible particles in parenteral dosage forms ...
Yu. V. Olefir   +7 more
doaj  

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