Results 71 to 80 of about 1,477,560 (316)

The evaluation of scientific productivity.

Historia, ciencias, saude--Manguinhos, 2018
The paper examines the evaluation of scientific productivity. It analyzes the metrification of the evaluation of scientific production, as well as the historical construction, and current uses of scientific evaluation. It argues that this process contains a paradox: the more that metrics become impersonal, the less they are recognized by scientists ...
Marcos Antônio, Mattedi, Maiko Rafael, Spiess   +1 more
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Pattern-Based Evaluation of Scientific Workflow Management Systems

, 2011
In recent years several scientific Workflow Management Systems (WfMSs) have been developed with the aim to automate large scale scientific experiments. As yet, many offerings have been developed, but none of them has been promoted as an accepted standard.
Migliorini, Sara, La Rosa, Marcello, Gambini, Mauro, ter Hofstede, Arthur H.M.   +3 more
core  

Evaluation as a Cognitive Process

, 2007
Evaluation is one of a number of so-called ‘higher order’ cognitive processes that are involved in the brain’s survival activities, including those extensions of basic coping processes (such as concept formation) that go into scientific and technological
Scriven, Michael, Michael Scriven
core   +1 more source

Pharmacogenetic testing in the treatment of type 2 diabetes with sulfonylurea drugs

Регуляторные исследования и экспертиза лекарственных средств, 2018
The article analyses scientific literature on the use of pharmacogenetic testing to optimize sulfonylurea treatment of patients with type 2 diabetes.
G. I. Gorodetskaya, V. G. Kukes, S. A. Belkov, R. E. Kazakov, S. Yu. Serebrova, O. V. Muslimova, T. A. Rodina, A. A. Aleksandrov   +7 more
doaj  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Scientific realism and the history of science [PDF]

, 2005
The paper considers the two main challenges to scientific realism, stemming from confirmation holism and the underdetermination thesis as well as from semantic holism and the incommensurability thesis. Against the first challenge, it is argued that there
Esfeld, Michael
core  

A Critical-Historical Review of Program Evaluation and the Emerging Motif ‘Evaluation Science’

, 2020
Background: It is important to distinguish between evaluation as an inherent, automatic, affective process and Program Evaluation (Evaluation, with capitalised ‘E’) as an institution, and equally important to consider what a good understanding of ...
Fear, William James, William James Fear
core   +1 more source

Determination of visible particles in parenteral dosage forms and ophthalmic dosage forms

Регуляторные исследования и экспертиза лекарственных средств, 2018
The present article describes the approaches to the choice of methods for assessing the content of visible particles in parenteral and ophthalmic dosage forms, recognized in general pharmacopoeia monograph «Visible particles in parenteral dosage forms ...
Yu. V. Olefir, T. N. Bokovikova, L. A. Stronova, E. P. Gernikova, L. I. Mitkina, S. A. Manaeva, Yu. B. Purim, A. V. Pichugin   +7 more
doaj  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source