Results 71 to 80 of about 11,994,000 (257)

An Evaluation of the World Bank Group’s Global Convening

, 2020
This first-of-its-kind evaluation assesses the scope of the World Bank Group’s convening power and how effectively it is deployed. The report finds that the Bank Group’s comparative advantages give it strong
Independent Evaluation Group
core   +1 more source

Formatting evaluation reports at IDRC

, 2012
French version available in IDRC Digital Library: Présentation des rapports d'évaluation au CRDIThis one-pager provides a guideline to the structure and formatting of project summaries, evaluations and annexes for research partners, awardees, staff ...
IDRC. Evaluation Unit
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Analysis of Batch to Batch Consistency of a Locally Produced Influenza Vaccine for the 2017–2018 Influenza Season

Биопрепараты: Профилактика, диагностика, лечение, 2018
The efficacy of influenza vaccines has been a matter of considerable debate ever since the development of the first influenza vaccine. The efficacy of currently used influenza vaccines depends on many  factors, including the strain composition, the ...
P. V. Demidova, K. M. Mefed, D. S. Davydov, K. A. Sarkisyan, A. A. Movsesyants, V. A. Merkulov   +5 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Current Approaches to Valerian Tincture Standardisation in Terms of Assay

Регуляторные исследования и экспертиза лекарственных средств, 2019
The quality control of the «Valerian rhizome and roots» herbal substance is carried out using high performance liquid chromatography (HPLC) according to the State Pharmacopoeia of the Russian Federation, XIV edition.
N. P. Antonova, E. P. Shefer, A. M. Kalinin, N. E. Semenova, S. S. Prokhvatilova, I. M. Morgunov   +5 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

An Evaluation of World Bank Group Support to the Reform of State-Owned Enterprises, FY08-18

, 2020
State Owned Enterprises (SOEs) play a major role in many developing and emerging economies, where governments use them to achieve economic, social, and political objectives. SOEs deliver and extend access to
Independent Evaluation Group
core   +1 more source