Results 81 to 90 of about 11,994,000 (257)
Регуляторные исследования и экспертиза лекарственных средств, 2018 The article describes validation of the procedure for determination of amino acids composition of glatiramer acetate by C-13 NMR spectroscopy. The procedure makes it possible to determine the molar ratio of amino acids present in glatiramer acetate with ...
N. E. Kuz’Mina +6 more
doaj
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Results of an opinion poll devoted to unification of instructions for interchangeable medicines
Регуляторные исследования и экспертиза лекарственных средств, 2018 The article discusses the results of an opinion poll among healthcare professionals and pharmacists devoted to finding out their attitude to the main problems associated with instructions for medicinal products. It was discovered that there was a lack of
N. G. Goloenko +6 more
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A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Vaccine Safety and Efficacy in Preventing Rotavirus Infection
Биопрепараты: Профилактика, диагностика, лечение, 2019 The rotavirus infection causes acute gastroenteritis and is a major cause of lethal severe dehydrating diarrhoea in children under 5 years of age worldwide.
V. A. Shevtsov +5 more
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
The development of microbiological methods for drug analysis
Регуляторные исследования и экспертиза лекарственных средств, 2018 The article presents the review of the national regulatory documents on drug testing for microbiological characteristics, such as «Sterility», «Microbiological Purity» etc.
O. V. Gunar +6 more
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A critical scientific evaluation of a purportedly negative data report - response to Seneviratne et al. 2022. [PDF]
Front Psychiatry, 2023 Johnson B +4 more
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Modern biological/biotechnological medicinal products. Topical issues and prospects for development
Биопрепараты: Профилактика, диагностика, лечение, 2018 The review provides with the information, related to the development, research and registration of new biological preparations, including the issues of terminology and classification.
Yu. V. Olefir +6 more
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