Results 71 to 80 of about 22,383,729 (330)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

METHODOLOGICAL APPROACHES TO EXPERT EVALUATION OF PRECLINICAL AND CLINICAL TRIALS OF HUMAN IMMUNOGLOBULIN PRODUCTS

Медицинская иммунология, 2017
The article considers the experience of Russian and leading foreign regulatory agencies in organisation and conduction of preclinical and clinical trials of human immunoglobulin products.
V. B. Ivanov, V. D. Mosyagin, E. Yu. Kudasheva, Yu. V. Olefir, V. A. Merkulov, I. V. Borisevitch, V. P. Bondarev   +6 more
doaj   +1 more source

A proposal for the evaluation of adaptive information retrieval systems using simulated interaction [PDF]

, 2010
The Centre for Next Generation Localisation (CNGL) is involved in building interactive adaptive systems which combine Information Retrieval (IR), Adaptive Hypermedia (AH) and adaptive web techniques and technologies.
Jones, Gareth J.F., Lawless, Séamus, Li, Wei B., Mulwa, Catherine   +3 more
core   +1 more source

Can We Count on Social Media Metrics? First Insights into the Active Scholarly Use of Social Media

, 2018
Measuring research impact is important for ranking publications in academic search engines and for research evaluation. Social media metrics or altmetrics measure the impact of scientific work based on social media activity.
Kling, Christoph Carl, Lemke, Steffen, Mazarakis, Athanasios, Mehrazar, Maryam, Peters, Isabella   +4 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Analysis of a sociological survey on information and educational needs of specialists in the field of medicines circulation as regards the issue of medicines interchangeability

Регуляторные исследования и экспертиза лекарственных средств, 2018
The article summarises the results of a 2015 survey of healthcare professionals and pharmacists that was aimed to reveal their educational needs on the subject of interchangeable medicines.
N. G. Goloenko, R. I. Yagudina, B. K. Romanov, R. N. Alyautdin, D. G. Karapetyan, E. G. Zelenova, E. E. Arinina, A. Yu. Kulikov, M. V. Protsenko, G. T. Abdrashitova   +9 more
doaj  

Peer review and in-depth interviews with publishers as a means of assessing quality of research monographs [PDF]

, 2008
It has often been observed that evaluating scientific activity in the Humanities and in some of the Social Sciences needs to involve a study of monographs, as they are often the preferred mean of publication by scientists in these fields.
Giménez-Toledo, Elea, Román, Adelaida
core  

Neurodevelopmental Outcomes in Children With Congenital Heart Disease: Evaluation and Management A Scientific Statement From the American Heart Association

Circulation, 2012
Background— The goal of this statement was to review the available literature on surveillance, screening, evaluation, and management strategies and put forward a scientific statement that would comprehensively review the literature and create ...
B. Marino, P. Lipkin, Jane W. Newburger, G. Peacock, M. Gerdes, J. W. Gaynor, Kathleen Mussatto, K. Uzark, C. S. Goldberg, W. Johnson, Jennifer S. Li, Sabrina E. Smith, David C. Bellinger, W. Mahle   +13 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source