Results 31 to 40 of about 8,060,325 (282)

Code of conduct for scientific integrity [PDF]

, 2021
The scientific landscape has changed considerably since the Swiss Academies of Arts and Sciences published Integrity in scientific research: Principles and procedures in 2008. Consequently, an expert group was set up with members from the Swiss Academies
Pirinoli, Christine, Eglin, Noëmi, Aebi-Müller, Regina E, Aebi-Müller, Regina E., Röthlisberger, Markus, Hoffmeyer, Pierre, Spycher, Karin M., Lautenschütz, C.Claudia, Lienhard, Andreas, Spycher, Karin M, Blatter, Inge, Lautenschütz, Claudia, Brigger, Joël, Constable, Edwin Charles   +13 more
core   +1 more source

Andean Fabaceae Species with Pharmacological Potential: Exploration of Antioxidant, Anticarcinogenic, and Antimicrobial Properties

Agriculture
The objective of the present study was to explore the pharmacological potential of three Andean Fabaceae species—Prosopis pallida (algarrobo), Caesalpinia spinosa (tara), and Inga feuilleei (pacae)—as well as their phytochemical composition and ...
Jhoseline Stayce Guillén-Sánchez, Walter Rojas-Villacorta, Ricardo Diego Duarte Galhardo de Albuquerque   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Health research protocols: a template for empirical bioethics and other investigations

Health Research Policy and Systems
We have formalized a protocol template suitable for all types of humanities and social sciences investigations in the domain of health, including empirical bioethics in particular.
Henri-Corto Stoeklé, Christian Hervé
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

United States Department of Labor Scientific Integrity Policy [PDF]

, 2023
United States Department of Labor Scientific Integrity ...

core  

SCIENCE AND HOMOSEXUALITY: POLITICAL BIAS IN MODERN ACADEMIA

Russian Journal of Education and Psychology, 2019
Allegations like “proven genetic reason for homosexuality” or “proven inefficacy of sexual orientation change efforts” are put forward at popular science educational events for scientifically unsophisticated people.
Viktor Grigorievitsch Lysov
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source