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Conference Report: Scientific Integrity in Qualitative Research (SCIQUAL) Seminar 2017

Forum: Qualitative Social Research, 2017
The Scientific Integrity in Qualitative Research (SCIQUAL) 2017 seminar focused on the basic rules of good scientific practice and researchers' commitment to (or lack thereof in) adhering to these rules.
Lakshmi Balachandran Nair
doaj   +1 more source

Maintaining the integrity of the scientific record [PDF]

Journal of Experimental Biology, 2008
This issue of The Journal of Experimental Biology (JEB) sees our first retraction of a published article ([p. 3764][1]). To put this into context, this is only one of the >400 Research Articles published in JEB this year and is the first retraction since the journal started in 1923.
Hoppeler, Hans-Heinrich, Handel, Michaela, Moulton, O Claire   +2 more
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Scientific Integrity in Educational Research Processes [PDF]

, 2023
The academic and scientific community must conduct research with the accountability, ethics, truthfulness, integrity, and respect that is necessary. The omission or lack of academic integrity on the part of researchers is influenced by several variables:
Patricia Medina Zuta, Barón-Velandia, Benjamín, Benjamín Barón-Velandia, Canchola González, José Antonio, José Antonio Canchola González, Medina Zuta, Patricia   +5 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

United States Framework for Federal Scientific Integrity Policy and Practice [PDF]

, 2023
United States Framework for Federal Scientific Integrity Policy and ...

core  

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

From a voluntary vaccination policy to mandatory vaccination against COVID-19 in cancer patients: an empirical and interdisciplinary study in bioethics

BMC Medical Ethics, 2022
Background At the start of 2021, oncologists lacked the necessary scientific knowledge to adapt their clinical practices optimally when faced with cancer patients refusing or reluctant to be vaccinated against COVID-19, despite the marked vulnerability ...
Henri-Corto Stoeklé, Sakina Sekkate, Elisabeth Angellier, Titouan Kennel, Asmahane Benmaziane, May Mabro, Jean-François Geay, Philippe Beuzeboc, Christian Hervé   +8 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Penser l’indissociabilité de l’éthique de la recherche, de l’intégrité scientifique et de la responsabilité sociale des sciences

Revue d'anthropologie des connaissances, 2019
With ethical questions about scientific research becoming increasingly institutionalized, we posit the need for a conceptual clarification of research ethics, scientific integrity, and social responsibility.
Léo Coutellec
doaj   +1 more source