Results 71 to 80 of about 36,943,093 (318)

Six Signs of Scientism [PDF]

open access: yes, 2010
As the English word “scientism” is currently used, it is a trivial verbal truth that scientism—an inappropriately deferential attitude to science—should be avoided.
Haack, Susan
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

The methodology of natural sciences in antiquity and the second book of Galen’s De placitis Hippocratis et Platonis [PDF]

open access: yesSCHOLE, 2015
In this article, based on the second book of Galen’s De placitis Hippocratis et Platonis, we analyze scientific method of the famous anatomist and philosopher.
Koptseva, Natalia   +2 more
doaj  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

On Political Economy and Economics as the Branches of Economic Knowledge [PDF]

open access: yesProblemi Ekonomiki, 2018
The article is dedicated to the methodological discourse on certain aspects of the improvement of the domestic economic terminology system and objective changes in the national economic science and education at the end of the 20th - beginning of the 21st
Panchyshyn Stepan M.   +1 more
doaj  

METHODOLOGY IN SCIENCE AND RELIGION: A REPLY TO CRITICS

open access: yesZygon, 2020
Debates about methodology have been central to the emergence of the “field of science of religion.” Two questions that have motivated scholars in that field over the past half century: “is it theoretically justifiable to bring scientific and religious ...
doaj   +2 more sources

Subject aspect of the idea of alternativeness

open access: yesИнтеллект. Инновации. Инвестиции, 2020
The purpose of the article is to analyze the methodological foundations of sociological, ideological and political concepts of pluralism. It is possible that goals of this nature may not cause enthusiasm among rationalist philosophers.
O. V. Kuznetsov , M. A. Pletneva
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

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