Results 81 to 90 of about 36,943,093 (318)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Replication and the Establishment of Scientific Truth
Frontiers in Psychology, 2020 The idea of replication is based on the premise that there are empirical regularities or universal laws to be replicated and verified, and the scientific method is adequate for doing it.
Seppo E. Iso-Ahola
doaj +1 more source
Non-deterministic random bit generator based on electronics noise
, 2003 Non-deterministic random bits are needed in many scientific fields. Unfortunately today's computers are very limited in ability to produce them. We present here a method for extraction of non-deterministic random bits from random physics processes, and ...
Stipčević, Mario
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Scientific method of preparing homoeopathic nosodes
, 2014 Introduction: Nosodes are homoeopathic preparations sourced from biological materials such as diseased tissues, organisms, cultures (bacteria, fungi, and viruses), or parasites, or from decomposed products from humans or animals.
R. Shah
semanticscholar +1 more source
Enhancing Effective Instrument Resolution by an Analog Method Scientific Report No. 280 [PDF]
Analog computer using deconvolution to improve resolution of analytical ...
Zabielski, M. F.
core +1 more source
Coronagraphic phase diversity: performance study and laboratory demonstration
, 2013 The final performance of current and future instruments dedicated to exoplanet detection and characterization (such as SPHERE on the European Very Large Telescope, GPI on Gemini North, or future instruments on Extremely Large Telescopes) is limited by ...
Mugnier, L. M. +2 more
core +3 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source