Results 11 to 20 of about 1,654,559 (261)

In-vivo expressed Mycobacterium tuberculosis antigens recognised in three mouse strains after infection and BCG vaccination

open access: yesnpj Vaccines, 2021
Novel tuberculosis (TB)-vaccines preferably should (i) boost host immune responses induced by previous BCG vaccination and (ii) be directed against Mycobacterium tuberculosis (Mtb) proteins expressed throughout the Mtb infection-cycle.
Mariateresa Coppola   +7 more
doaj   +1 more source

CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors

open access: yesSignal Transduction and Targeted Therapy, 2023
As the most prevalent neurodevelopmental disorders in children, autism spectrum disorders (ASD) are characterized by deficits in language development, social interaction, and repetitive behaviors or inflexible interests. Contactin associated protein like
Jing Zhang   +11 more
doaj   +1 more source

Intuition and Awareness of Abstract Models: A Challenge for Realists

open access: yesPhilosophies, 2018
It is plausible to think that, in order to actively employ models in their inquiries, scientists should be aware of their existence. The question is especially puzzling for realists in the case of abstract models, since it is not obvious how this is ...
Dimitris Kilakos
doaj   +1 more source

History of the Concept of Similarity in Natural Sciences

open access: yesConatus - Journal of Philosophy, 2021
The concept of similarity has been discussed by many scientists and philosophers since ancient times. Thales of Miletus, Euclid, Aristotle, Galileo, Newton, Edgar Buckingham, and the modern philosopher of science Susan G.
Virginia John Grigoriadou   +2 more
doaj   +1 more source

Stochastic modeling of scientific impact [PDF]

open access: yesEPL (Europhysics Letters), 2021
Accepted for publication by Europhysics ...
openaire   +3 more sources

A glucose-blue light AND gate-controlled chemi-optogenetic cell-implanted therapy for treating type-1 diabetes in mice

open access: yesFrontiers in Bioengineering and Biotechnology, 2023
Exogenous insulin therapy is the mainstay treatment for Type-1 diabetes (T1D) caused by insulin deficiency. A fine-tuned insulin supply system is important to maintain the glucose homeostasis.
Chi-Yu Li   +31 more
doaj   +1 more source

Parallel Rayleigh Quotient Optimization with FSAI-Based Preconditioning

open access: yesJournal of Applied Mathematics, 2012
The present paper describes a parallel preconditioned algorithm for the solution of partial eigenvalue problems for large sparse symmetric matrices, on parallel computers.
Luca Bergamaschi   +2 more
doaj   +1 more source

Teaching about Scientific Models in a Science Content Course

open access: yesEducación Química, 2018
Scientists construct and use models as part of scientific inquiry. Thus, learners should be knowledgeable about what scientific models are, how they are developed, and how they are used by scientists.
Renée Schwartz, Brandy Skjold
doaj   +1 more source

Transfer and templates in scientific modelling [PDF]

open access: yesStudies in History and Philosophy of Science Part A, 2019
The notion of template has been advocated by Paul Humphreys and others as an illuminating unit of analysis in the philosophy of scientific modelling. Templates are supposed to have the dual functions of representing target systems and of facilitating quantitative manipulation.
Houkes, Wybo, Zwart, Sjoerd D.
openaire   +2 more sources

Dalla macchina all’opera d’arte. Metafore del vivente nella biologia sperimentale ottocentesca

open access: yesAisthesis, 2014
The paper reconstructs an emblematic case of the relationship between scientific models and metaphors, showing how it is just a metaphor to shape the new image of the life promoted by Claude Bernard in the context of nineteenth-century biology.
Annamaria Contini
doaj   +3 more sources

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