Results 221 to 230 of about 4,444,969 (268)

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Open science and epistemic equity: opportunities and challenges in the contemporary research ecosystem. [PDF]

BMC Res Notes
Farrow R.
europepmc   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Artificial intelligence and genomic data privacy: Balancing innovation with security. [PDF]

Mol Biol Res Commun
Kohan L.
europepmc   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Unlocking the benefits of transparent and reusable science for climate risk management. [PDF]

Proc Natl Acad Sci U S A
Pollack AB, Auermuller L, Burleyson CD, Campbell J, Condon M, Cooper C, Coronese M, Dangendorf S, Doss-Gollin J, Hegde P, Helgeson C, Kopp RE, Kwakkel J, Lesk C, Mankin J, Nicholas RE, Rice J, Roth S, Srikrishnan V, Scheeler M, Tuana N, Vernon C, Zhao M, Keller K.   +23 more
europepmc   +1 more source

Scientific Models as Works [PDF]

, 2012
openaire   +1 more source

Genomic selection and reproducibility: are complex models distracting us from true scientific validity in the presence of genotype-by-environment interaction? [PDF]

G3 (Bethesda)
Howard R, Lipka AE.
europepmc   +1 more source

Correction: Exploration of shared pathogenic factors and causative genes in early-stage endometrial cancer and osteoarthritis. [PDF]

Sci Rep
Bai Y, Luo S, Shuai R, Zhang X, Yuan L, Liu D.   +5 more
europepmc   +1 more source