Results 71 to 80 of about 8,311,638 (299)

Ranking the Scientific Output of Researchers in Fractional Calculus [PDF]

Fractional Calculus and Applied Analysis, 2019
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Tenreiro Machado, J. A., Lopes, António M.   +1 more
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Quantification of Scientific Output in Cardiovascular Medicine: A Perspective Based on Global Data [PDF]

, 2013
AIMS: We sought to explore whether global and regional scientific output in cardiovascular medicine is associated with economic variables and follows the same trend as medicine and as science overall.
Regar, Evelyn, Lemos, Pedro A., Rodríguez, Alfredo, Ayala, Francisco, Ong, Andrew T. L., Schoenhagen, Paul, Aoki, Jiro, Barbenza, Ezequiel, McFadden, Eugene, Saia, Francesco, Tsuchida, Keiichi, Biondi Zoccai, Giuseppe, Arampatzis, Chourmouzios A., Bruining, Nico, del Valle Fernández, Raquel, Milei, Jose, Rodriguez Granillo, Gaston Alfredo, Serruys, Patrick W., Garcia Garcia, Hector M., Valgimigli, Marco   +19 more
core   +2 more sources

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Mapping the intellectual structure of scientific outputs in the subject area of public law in the Web of Science database [PDF]

مجله علم‌سنجی کاسپین
Background and aim: Given the fundamental role of public law in regulating the relationship between the state and citizens and safeguarding fundamental rights, examining the intellectual structure and scientific trends in this field is essential for the ...
Omid Shirzad, Ismael Mostafavi, Seyedeh Zahra Hosseini Rad   +2 more
doaj  

Scientific Publication Packages – A Selective Approach to the Communication and Archival of Scientific Output [PDF]

International Journal of Digital Curation, 2008
The use of digital technologies within research has led to a proliferation of data, many new forms of research output and new modes of presentation and analysis. Many scientific communities are struggling with the challenge of how to manage the terabytes of data and new forms of output, they are producing.
openaire   +10 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Scientific Output and GDP: Evidence from Countries around the World [PDF]

, 2011
Scientific output is one of the important determinants of economic development in countries around the world. The extremely high scientific productivity of developing countries can be corrected by increased funding as investment on publications and also ...
Samimi, Ahmad Jafari
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source