Results 61 to 70 of about 166,748 (266)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Scientific Publication Packages – A Selective Approach to the Communication and Archival of Scientific Output [PDF]

International Journal of Digital Curation, 2008
The use of digital technologies within research has led to a proliferation of data, many new forms of research output and new modes of presentation and analysis. Many scientific communities are struggling with the challenge of how to manage the terabytes of data and new forms of output, they are producing.
openaire   +10 more sources

A comparative study on the scientific outputs of agricultural faculty members at State Universities in Khuzestan [PDF]

مجله علم‌سنجی کاسپین, 2018
Background and aim: Today, the scientific outputs of universities are quantitatively and qualitatively measured using scientometrics on which the scientific progress of these institutions is evaluated.
Zahed Bigdeli, Bahman Khosravipour, Maryam Zanganeh   +2 more
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Iranian scientific outputs in the field of energy and fuel, and their comparison with those of the Middle East countries [PDF]

مجله علم‌سنجی کاسپین, 2018
Background and aim: Today, the quantitative and qualitative research on the scientific outputs of various fields has been considered in universities and scientific centers.
Mohsen Fazeli varzaneh, Mahdi Bahmani, Erfan Ghaderi Azad   +2 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Evaluation of scientific output in Dentistry in Spanish Universities

Medicina Oral Patología Oral y Cirugia Bucal, 2017
The aim of this study was to assess the scientific output of Spanish universities that offer a bachelor's degree in dentistry through the use of various bibliometric indicators.A total of 21 universities offered a bachelor's degree in dentistry in academic year 2016-2017. The search for papers published by authors associated with these institutions was
Flor Martínez, María De la, Galindo Moreno, Pablo, Sánchez Fernández, E., Abadal, Ernest, Cobo, Manuel-Jesús, Herrera-Viedma, Enrique   +5 more
openaire   +5 more sources

Scientific collaboration of authors in Payesh Journal from 2012-2019 [PDF]

مجله علم‌سنجی کاسپین, 2020
Background and aim: Scientific collaboration among medical authors is growing. Due to the role of scientific collaboration in improvement of quality and quantity of scientific outputs, the aim of this study was to reflect the scientific collaboration ...
Amrollah Shamsi, Hadiseh Heidari, Zohreh Chanbari   +2 more
doaj