Results 71 to 80 of about 166,748 (266)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Mapping the Scientific Outputs of Allameh Tabataba'i University from 1974 to 2024 [PDF]
بازیابی دانش و نظامهای معناییIntroductionScientific outputs that report on the findings of scientific research play a crucial role in enhancing knowledge, advancing science, and promoting research within academic communities.
Seyed Mahdi Taheri, Negin Shokrzadeh
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Scientific Outputs Regarding Occupational Health among Female Workers
International Journal of Occupational Hygiene, 2015 Although the International Labor Organization (ILO) has reported that two-thirds of the world’s occupations belong to women, a few studies regarding employed women have been conducted.
MARYAM NIKPOUR +2 more
doaj
Comparison between Iranian health scientific outputs and disease burden [PDF]
مجله علمسنجی کاسپین, 2019 Background and aim: One of the most important infrastructures for the development and progress of countries is scientific outputs and targeted research to meet the needs of society and reduce the disease burden. The aim of this study was to determine the
Arezoo Ghamgosar +3 more
doaj
Presenting A Paradigm Model for the Effect of Educational and Research Interactions Between Faculty Members, Students, and Librarians on Scientific Outputs Using a Grounded Theory Approach [PDF]
نشریه مطالعات دانشپژوهیPurpose: This study aimed to develop a model illustrating the impact of research interactions among faculty members, students, and librarians on scientific outputs, employing a grounded theory approach.Methodology: This qualitative research utilized a ...
Safiyeh tahmasebi Limooni
doaj +1 more source
Global scientific outputs of extracorporeal membrane oxygenation in COVID-19: A bibliometric overview. [PDF]
Perfusion, 2023 Kosovali BD, Mutlu NM.
europepmc +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source