Results 111 to 120 of about 1,160,518 (299)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Publishing activity of Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences
Библиосфера, 2015 The history of the publishing activity of the large scientific subdivision of the Russian Academy of Sciences is presented for the first time. The editorial-publishing department of Komi Scientific Centre is a leader of the scientific book publishing in ...
L. P. Roshchevskaya
doaj
Front Matter -- PREFACE -- ACKNOWLEDGMENTS -- Contents -- 1. Introductory Remarks -- 2. Keynote Address -- 3. Costs of Publication -- 4. Publication Business Models and Revenue -- 5. Legal Issues in Production, Dissemination, and Use -- 6.
Council, National Research. +3 more
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Strategic Publishing Rules – a Manual for Researchers
, 2011 At Blekinge Institute of Technology (BTH) attempts have been made to with different means motivate researchers to publish in ISI-ranked journals as an adjustment to the resource distribution- and evaluation system of Swedish research policy.
Grahn, Håkan, Linde, Peter
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Embracing the use of artificial intelligence in scientific publishing
Generative artificial intelligence (AI) tools such as large language models (LLM) have begun to transform many industries, including health care. Scientific publishing is no exception.
Garcia Elorio, Ezequiel +11 more
core +1 more source