Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
The intellectual and moral integrity of bioethics: response to commentaries on A case study in unethical transgressive bioethics: \u27Letter of concern from bioethicists\u27 about the prenatal administration of dexamethasone . [PDF]
, 2010 In our target article we showed that the Letter of Concern (LoC) fails to meet accepted standards for presenting empirical data for the purpose of supplementing a normative claim and for argument-based normative ethics.
Brent, Robert L +3 more
core +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Measured Attention in Prolonged Over-Learned Response Tasks and its Correlation to High Level Scientific Reasoning and School Achievement [PDF]
, 2014 The relationship between attention and academic performance has been of interest starting with early studies on academic success and failure. In this study we examine how attention measured in simple and prolonged over-learned response tasks correlates ...
Hautamäki, Jarkko +3 more
core
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
The impact of the blended learning approach on the level of scientific reasoning in physics [PDF]
Nastava i VaspitanjeThe application of new technologies without changing the role of teachers and students in the education system does not necessarily mean a change in student performance. This research aims to examine the influence of active and passive engagement of high
Radulović Branka +2 more
doaj +1 more source
Legal theory and epistemic values: against authoritarian interpretivism [PDF]
, 2012 In his new book, R. Dworkin advocates the unity of values thesis. He wants to circumscribe morality as a proper epistemological domain which is methodologically different from scientific inquiry.
Caballero Lois, Cecilia +1 more
core
Cooperating Agents for 3D Scientific Data Interpretation
, 1999 Many organizations collect vast quantities of three-dimensional (3-D) scientific data in volumetric form for a range of purposes, including resource exploration, market forecasting, and process modelling.
Gallimore, R. J. +4 more
core +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source