Results 171 to 180 of about 22,645,468 (334)

Research on the Construction of Scientific and Technological Innovation Emergency System for Major Public Health Emergencies from the Perspective of Complex Adaptive System [PDF]

思文 张
openalex   +1 more source

INNOVATIVE SCIENTIFIC RESEARCH: THEORY AND PRACTICE

, 2023
Denis Vladlenov, Denis Vladlenov
openalex   +1 more source

Mapping Scientific Research on High-Intensity Interval Training (HIIT) in Overweight Populations (2011-2024). [PDF]

Sports (Basel)
Paucar-Uribe JD, Rendón-Sanchéz AJ, Peña-Giraldo MV, Forero González KR, Moreno ATS, Becerra-Patiño BA, Prieto Mondragon LDP, Olivares-Arancibia J, Yáñez-Sepúlveda R, López-Gil JF.   +9 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Pautes del Scientific Council de l'ERC per a l'accés obert (17 de setembre de 2007)

BiD: Textos Universitaris de Biblioteconomia i Documentació, 2008
European Research Council. Scientific Council
doaj  

The peculiarities of archival heuristics in seeking information on the history of Soviet industry of Sevastopol in the central archives (on the example of the source complex on the history of Sevastopol branch of the Central Research Institute “Compass” in the Central State Archive of Scientific and Technical Documentation of St. Petersburg)

, 2021
Anna Vasil'evna Kuz'mina, Roman Sergeevich Lyalin   +1 more
openalex   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Reframing the sex debate in scientific research: three frameworks to support rigor without rigidity. [PDF]

Biol Sex Differ
Ritz SA, DuBois LZ.
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source