Results 191 to 200 of about 9,382,254 (295)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Ensuring robustness in scientific research, split-root assays as an example case. [PDF]

Quant Plant Biol
Salvatore L, Pierik R, Kajala K, Ten Tusscher K.   +3 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Awareness of the dual-use dilemma in scientific research: reflections and challenges to Latin America. [PDF]

Front Bioeng Biotechnol
Flores-Coronado JA, Alanis-Valdez AY, Herrera-Saldivar MF, Flores-Flores AS, Vazquez-Guillen JM, Tamez-Guerra RS, Rodriguez-Padilla C.   +6 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Bridging Gaps: Promoting Scientific Research in AOCMF Asia Pacific and Comparison with Latin America. [PDF]

Craniomaxillofac Trauma Reconstr
Menon R, Kanno T, Leung YY, Thelekkat Y, Kulandaswamy GK.   +4 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Optimizing clinical scientific research: the cohort intervention random sampling study with historical controls. [PDF]

J Comp Eff Res
de Klerk ND, Berben PB, der Ven MV, Fransen AF, van der Hout-van der Jagt MB, Oei SG, van Laar JO, van den Heuvel ER.   +7 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Generalization bias in large language model summarization of scientific research. [PDF]

R Soc Open Sci
Peters U, Chin-Yee B.
europepmc   +1 more source