Results 171 to 180 of about 3,513,282 (267)

Mapping Scientific Research on High-Intensity Interval Training (HIIT) in Overweight Populations (2011-2024). [PDF]

Sports (Basel)
Paucar-Uribe JD, Rendón-Sanchéz AJ, Peña-Giraldo MV, Forero González KR, Moreno ATS, Becerra-Patiño BA, Prieto Mondragon LDP, Olivares-Arancibia J, Yáñez-Sepúlveda R, López-Gil JF.   +9 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Brazilian national telediagnosis platform: a data report for scientific research and public health improvement. [PDF]

Front Digit Health
Filho WSBR, de Sousa LAN, Pinto HA, Fontes RS, Caldeira Silva GJP, Fernandes F, Barbalho I, de Morais AHF, Arrais Júnior E, de Oliveira Barreto T, Teixeira CA, Henriques J, Machado GM, Valentim J, Coutinho KD, Valentim R.   +15 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Artificial intelligence-enabled electrocardiography from scientific research to clinical application. [PDF]

EMBO Mol Med
Lin CS, Liu WT, Chen YH, Lin SH, Lin C.
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Reframing the sex debate in scientific research: three frameworks to support rigor without rigidity. [PDF]

Biol Sex Differ
Ritz SA, DuBois LZ.
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Negotiating the ethical frontier: the double-edged role of generative AI in scientific research. [PDF]

Ann Med Surg (Lond)
Haider E, Irshad NUN, Imran SB.
europepmc   +1 more source