Results 81 to 90 of about 2,588,444 (261)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The workings of scientific communities
, 2001 No abstract is available for this item.
Cowan Robin, Jonard Nicolas
openaire +3 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
ORIGINALITY - CONDITION FOR PROTECTION OF SCIENTIFIC WORKS [PDF]
Challenges of the Knowledge Society, 2014 The Doctrine defines originality as a combination of fancy, audacity, individuality and novelty. This ensemble of ideas meant to define originality appeals to the patents/ certificates Law for which novelty/ innovation is not enough.
Viorel ROŞ, Andreea LIVĂDARIU
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Вестник университетаThe article is devoted to the study of the features of processing large amounts of data using the Python programming language. Unlike tabular processors or finished software products, programming languages offer the user a flexible toolkit ...
E. S. Konishchev
doaj +1 more source
THE MEANINGS, PURPOSE AND FUNCTION OF THE CONTEMPORARY RUSSIAN GRADUATE SCHOOL: PROBLEM ANALYSIS
Вестник Северо-Кавказского федерального университета, 2022 The article deals with various aspects of understanding of the modern model of the Russian postgraduate school as a level of higher education. The scientific, normative, statistical materials and data revealing the target and functional basis of ...
Sergey Bobryshov, Natalia Dzhegutanova
doaj
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source