Results 121 to 130 of about 827,817 (314)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Star Scientists, Innovation and Regional and National Immigration [PDF]
We follow the careers 1981-2004 of 5401 star scientists listed in ISI HighlyCitedSM as most highly cited by their peers. Their number in a US region or a top-25 science and technology (S&T) country significantly increases the probability of firm entry in
Michael R. Darby, Lynne G. Zucker
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Highlights from First International Conference on Cancer Health Disparities
, 2022 The first International Conference on Cancer Health Disparities (ICCHD) was held on August 13-14, 2021, in Harlingen, TX, USA. This two-day ICCHD-2021 was organized by the University of Texas Rio Grande Valley, School of Medicine (UTRGV-SOM).
Tsin, Andrew +3 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Social scientists at work on the electronic network [PDF]
, 1992 The purpose of this article is to contribute to our stock of knowledge about who uses networks, how they are used, and what contribution the networks make to advancing the scientific enterprise.
Robbin, Alice
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Вестник Мининского университета, 2017 The present article analyzes the history of formation and development of psychological education in Gorky Statе Pedagogical University (GSPU). The key stages and directions of scientific and pedagogical activity of psychological department of GSPU are ...
N. V. Shutova, V. V. Kisova
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Statistics for Scientists and Engineers
, 2015 This book provides the theoretical framework needed to build, analyze and interpret various statistical models. It helps readers choose the correct model, distinguish among various choices that best captures the data, or solve the problem at hand.
Shanmugam, Ramalingam +1 more
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Історія науки і технікиThe article examines the work, scientific achievements, and contribution of Doctor of Medical Sciences, Professor Viktor Rafailovich Faitelberg-Blank and Candidate of Medical Sciences, Associate Professor Maria Vasilievna Kropelnitskaya to the ...
Zhanar Mukhangaliyeva +2 more
doaj +1 more source