Results 131 to 140 of about 827,817 (314)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Naked Scientists Podcast

The Naked Scientists are "a media-savvy group of physicians and researchers from Cambridge University who use radio, live lectures, and the Internet to strip science down to its bare essentials, and promote it to the general public." They have

core  

Editorial

, 2017
In today’s world, understanding, preventing and curing cancer remains the top most challenge. Over the past several decades, there has been a substantial advancement in screening, diagnosis, prevention, and treatment of cancer.
Singh, Keshav K
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Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Antworten auf zentrale Fragen zur Einführung von CO2 Preisen

Diese Zusammenstellung einiger in der Öffentlichkeit häufig diskutierter Fragen zur CO2-Bepreisung bereitet den Stand der Forschung für Interessierte auf.LEUREZitierung: Mattauch, Linus, Felix Creutzig, Nils aus dem Moore, Max Franks, Franziska Funke ...
Loew, Thomas, Schmidt, Robert, Wallacher, Johannes, Drupp, Moritz, Neuhoff, Karsten, Kirchner, Mathias, Schwarze, Reimund, Franks, Max, Funke, Franziska, Sager, Lutz, Daub, Claus-Heinrich, Thalmann, Philippe, Hagedorn, Gregor, Neuweg, Isabella, Schwarz, Moritz, Voß, Achim, aus dem Moore, Nils, Ekardt, Felix, Siegmeier, Jan, Jakob, Michael, Creutzig, Felix, Mattauch, Linus, Peterson, Sonja, Roesti, Matthias, Beck, Marie-Luise, Kruse, Tobias, Schneider, Gerhard   +26 more
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Integrated Ocean Drilling Program Expedition 327 Preliminary Report: Juan de Fuca Ridge-Flank Hydrogeology The hydrogeologic architecture of basaltic oceanic crust: compartmentalization, anisotropy, microbiology, and crustal-scale properties on the eastern flank of Juan de Fuca Ridge, eastern Pacific Ocean, 5 July–5 September 2010

, 2010
Integrated Ocean Drilling Program (IODP) Expedition 327 and related experiments focus on understanding fluid–rock interactions in young, upper ocean crust on the eastern flank of the Juan de Fuca Ridge, delineating the magnitude and distribution of ...
Harris, Michelle, Expedition 327 Scientists,, Fisher, A.T.   +2 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source