Results 251 to 260 of about 827,817 (314)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Purpose, persistence, and progress: building the next generation of physician-scientists. [PDF]

J Clin Invest
Tang CY.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Drug Discovery in Africa. [PDF]

ACS Med Chem Lett
Dziwornu GA, Cheuka PM, Mayoka G.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Does love in the ivory tower fix the leaky pipeline? How academia's homogamous relationships shape careers. [PDF]

PLoS One
Velicu A, Fauvelais M, Jerke J, Rauhut H, Lemaitre B.   +4 more
europepmc   +1 more source

Do Intramural Career Development Programs Provide an Advantage to Rehabilitation Scientists Applying for Merit-Review Scientific Funding? A Retrospective Cohort Study. [PDF]

Am J Phys Med Rehabil
Fraser JJ, Schwinder EJ, Spaniol ED.
europepmc   +1 more source

Spark or Sound: How Two Differing Explanatory Strategies Impact the Debate on the Physical Nature of Neuronal Excitability. [PDF]

Membranes (Basel)
Drukarch B, Wilhelmus MMM.
europepmc   +1 more source

Trust undone: How COVID-19 coverage shaped scientists' trust in journalism and their willingness to engage with the media. [PDF]

Public Underst Sci
Marcinkowski F, de Haas H, Kohler S.
europepmc   +1 more source