Results 61 to 70 of about 24,789 (234)

Anti-proteinase 3 antibodies in diffuse systemic sclerosis (SSc) with normotensive renal impairment: is it suggestive for an overlapping between SSc and idiopathic vasculitis?

Reumatismo, 2001
Objective. To test the prevalence of anti-neutrophil cytoplasmic antibodies (ANCA) in systemic sclerosis (SSc) and to verify a possible association of ANCA with normotensive renal involvement in SSc.
F. Bellisai, G. Morozzi, M.R. Bacarelli, A. Radice, R.A. Sinico, J. Wieslander, G.D. Sebastiani, V. Campanella, R. Marcolongo, M. Galeazzi   +9 more
doaj   +1 more source

In systemic sclerosis skin perfusion of hands is reduced and may predict the occurrence of new digital ulcers [PDF]

, 2017
Systemic sclerosis (SSc) patients are at high risk for the development of ischemic digital ulcers (DUs). The aim of this study was to assess in SSc patients a correlation between skin perfusion evaluated by LDPI and DUs and to evaluate the prognostic ...
Barbano, Biagio, Barilaro, Giuseppe, Gasperini, Maria Ludovica, Gigante, Antonietta, Marra, Alessandro Maria, Quarta, Silvia, Rosato, Edoardo   +6 more
core   +1 more source

A Cooperative Release of Mitochondrial DNA From Platelets and Neutrophils Drives an Interferon Signature in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Mitochondria are organelles with a hypomethylated circular genome. Mitochondrial DNA (mtDNA) in the systemic circulation has been implicated in inflammation. This study investigates the role of circulating DNA in systemic sclerosis (SSc) and the cellular mechanisms governing its release.
Stavros Giaglis, André N. Tiaden, Simone Häner‐Massimi, Diego Kyburz, Cedric André, Anton Glück, Enrico Ferrero, Stuart Hawtin, Tobias Junt, Ulrich A. Walker   +9 more
wiley   +1 more source

Smoking in Systemic Sclerosis: a Longitudinal European Scleroderma Trials and Research Group Study [PDF]

, 2018
Data on the role of tobacco exposure in systemic sclerosis (SSc) severity and progression are scarce. We aimed to assess the effects of smoking on the evolution of pulmonary and skin manifestations in the EUSTAR ...
Airó, Paolo, Alegre-Sancho, Juan J, Allanore, Yannick, Caimmi, Cristian, Carreira, Patricia E, Cozzi, Franco, Czirják, Laszlo, De Langhe, Ellen, Del Galdo, Francesco, Denton, Christopher P, Distler, Oliver, EUSTAR coauthors, Hachulla, Eric, Henes, Jörg, Houssiau, Frédéric, Jaeger, Veronika K, Matucci-Cerinic, Marco, Müller-Ladner, Ulf, Rednic, Simona, Riccieri, Valeria, Rosato, Edoardo, Siegert, Elise, Smith, Vanessa, Ullman, Susanne, Valentini, Gabriele, Walker, Ulrich A   +25 more
core   +5 more sources

Long‐Term Outcomes of Reduced‐Intensity Conditioning Hematopoietic Stem Cell Transplantation for Patients With Systemic Sclerosis With Impaired Cardiac Function

Arthritis &Rheumatology, EarlyView.
Objective High‐intensity conditioning autologous hematopoietic stem cell transplantation (AHSCT) is standard of care for patients with advanced systemic sclerosis (SSc). The role of reduced‐intensity conditioning (RIC) before AHSCT in this population remains unclear.
Yonatan Lean, Carrie Richardson, Anthony J. Esposito, Katy Bedjeti, George E. Georges   +4 more
wiley   +1 more source

A case of Myhre syndrome mimicking juvenile scleroderma

Pediatric Rheumatology Online Journal, 2020
Background Myhre syndrome is a genetic disorder caused by gain of function mutations in the SMAD Family Member 4 (SMAD4) gene, resulting in progressive, proliferative skin and organ fibrosis.
Barbara Jensen, Rebecca James, Ying Hong, Ebun Omoyinmi, Clarissa Pilkington, Neil J. Sebire, Kevin J. Howell, Paul A. Brogan, Despina Eleftheriou   +8 more
doaj   +1 more source

Molecular subsets in the gene expression signatures of scleroderma skin. [PDF]

PLoS ONE, 2008
Scleroderma is a clinically heterogeneous disease with a complex phenotype. The disease is characterized by vascular dysfunction, tissue fibrosis, internal organ dysfunction, and immune dysfunction resulting in autoantibody production.We analyzed the ...
Ausra Milano, Sarah A Pendergrass, Jennifer L Sargent, Lacy K George, Timothy H McCalmont, M Kari Connolly, Michael L Whitfield   +6 more
doaj   +1 more source

Role of growth factors in the pathogenesis of tissue fibrosis in systemic sclerosis. [PDF]

, 2010
The most severe clinical and pathologic manifestations of systemic sclerosis (SSc) are the result of a fibrotic process characterized by the excessive and often progressive deposition of collagen and other connective tissue macromolecules in skin and ...
Castro, Susan V., Jimenez, Sergio A., Piera-Velazquez, Sonsoles   +2 more
core   +2 more sources

Impact of Evolving Treatment Patterns on Interstitial Lung Disease Progression in Systemic Sclerosis Using the European Scleroderma Trials and Research Database

Arthritis &Rheumatology, EarlyView.
Objective The treatment landscape for systemic sclerosis‐associated interstitial lung disease (SSc‐ILD) has evolved with increasingly available immunosuppressive therapies (ISTs) and antifibrotic treatments. However, their real‐world use remains unclear.
Corrado Campochiaro, Marie‐Elise Truchetet, Madelon Vonk, Giacomo De Luca, Giovanna Cuomo, Lidia P. Ananieva, Eric Hachulla, Vanessa Smith, Ana Maria Gheorghiu, Radim Becvar, Patricia Carreira, Nicolas Hunzelmann, Daniel E. Furst, Vera Ortiz‐Santamaria, Francesco Del Galdo, Marco Matucci‐Cerinic, Anna‐Maria Hoffmann‐Vold, EUSTAR collaborators   +17 more
wiley   +1 more source

Comparison between clinical and immunological features of scleroderma with and without interstitial lung disease

Journal of the Pakistan Medical Association
The study was conducted at the Fauji Foundation Hospital, Rawalpindi, Pakistan, from January 1, 2023, to December 31, 2023, and comprised 20 female patients ages 18-55 years having scleroderma. Overall, 14(70%) patients had diffuse scleroderma and 6(30%)
Muhammad Salman Mushtaq, Haris Gul, Muhammad Umer Daraz, Muhammad khan, Saba Samreen   +4 more
doaj   +1 more source