Results 101 to 110 of about 26,940 (220)

Characterization of Pulmonary Functional Abnormalities in Systemic Sclerosis Using Xenon MRI

Journal of Magnetic Resonance Imaging, Volume 64, Issue 3, Page 655-666, September 2026.
ABSTRACT Background Xenon MRI is increasingly used to evaluate patients with interstitial lung disease (ILD) and pulmonary hypertension (PH), both of which are common manifestations of systemic sclerosis (SSc). As such, Xe‐MRI may be suited to interrogate lung function impairment in SSc.
Dawson Shaver, Steven Haworth, Evan Graumann, Bradie Frizzell, David H. Lee, Jiwoong Choi, Chase S. Hall, Scott M. Matson, Mark Hamblin, Mario Castro, Paul S. Schmidt, Peter J. Niedbalski   +11 more
wiley   +1 more source

Ventilation Imaging of the Lung at 0.55T With Continuous Slice Cycling

Magnetic Resonance in Medicine, Volume 96, Issue 3, Page 1235-1244, September 2026.
ABSTRACT Purpose To propose and evaluate a novel method for pulmonary ventilation imaging, offering considerably improved SNR. Methods A continuous slice cycling (CSC) acquisition scheme is proposed to exclusively capture signal modulations from respiratory motion with increased SNR.
Andrea Leuthard, Grzegorz Bauman, Katrin E. Hostettler, Maurice Pradella, Oliver Bieri   +4 more
wiley   +1 more source

A Cross Sectional Study of Cardiopulmonary Complications and Severity of Pulmonary Hypertension and Lung Fibrosis in Patients With Systemic Sclerosis

The Turkish Journal of Gastroenterology, 2015
Objectives: This study aims to identify the characteristics of scleroderma patients in terms of sociodemographic and clinical characteristics and severity of lung fibrosis and pulmonary hypertension and to show the association between European ...
Wan Ahmad Syahril Rozli WAN ALI, Mohd Shahrir MOHAMED SAID, Syahrul Sazliyana SHAHARIR, Andrea Yu Lin BAN, Rizuana Iqbal HUSSAIN, Azmillah ROSMAN   +5 more
doaj  

Scleroderma-like Lesions in a Patient Undergoing Combined Pembrolizumab and Routine Chemotherapy: A Case Report and Literature Review

Medicina
Triple-negative breast cancer (TNBC) represents a challenging malignancy with limited treatment options and a poor prognosis. Adjuvant therapies, including chemotherapy and immune checkpoint inhibitors (ICI), are commonly employed following breast ...
Hung-Liang Pai, Chin-Yin Liu, Ming-Hsin Yeh   +2 more
doaj   +1 more source

Lipodystrophy and adipose tissue recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis

The Journal of Pathology, Volume 270, Issue 1, Page 98-113, September 2026.
Abstract Acquired lipodystrophy in the dermal white adipose tissue (DWAT) is an early phenotype of skin fibrosis, followed by the accumulation of extracellular matrix (ECM). Lipodystrophy syndromes are estimated to affect 1 in 20,000 people and are associated with metabolic comorbidities.
Suneeti R Madhavan, Piper Moore, Rohan Varshney, Miles Montegut, Qiannan Ma, Kayla Klatt, Reshmi Parameswaran, Elif G Ertugral, Chandrasekhar R Kothapalli, Michael C Rudolph, Radhika P Atit   +10 more
wiley   +1 more source

Clinical Trial: Effectiveness and Safety of a Novel Anal Insert Device for Treatment of Faecal Incontinence

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 5, Page 603-614, September 2026.
StaySure is a novel anal insert device that safely and effectively treats medically refractory faecal incontinence. Treatment reduced incontinence episodes by 69%, improved quality of life beyond clinically meaningful thresholds, and was well tolerated with no treatment‐related serious adverse events. ABSTRACT Background Treatment options for medically‐
Adil E. Bharucha, Ramesh Lamichhane, Joel G. Fletcher, Nicholas R. Oblizajek, Misha Gautam, Kent R. Bailey, Lawrence A. Szarka   +6 more
wiley   +1 more source

TRPA1 Regulates Fibrosis‐Associated Transcriptional Pathways in Human Lung Epithelial Cells

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Transient receptor potential ankyrin 1 (TRPA1) is a cation channel originally identified in lung fibroblasts and extensively studied in sensory neurons, where it is associated with pain and neurogenic inflammation. We and others have recently shown that TRPA1 is also expressed in lung epithelial cells and that its expression is regulated by ...
Leevi Halonen, Samu Luostarinen, Ida Valjus, Julia Vistbacka, Antti Pemmari, Eeva Moilanen   +5 more
wiley   +1 more source

Multiple External Invasive Root Resorption and Calcification in Systemic Sclerosis—Case Report

International Endodontic Journal, Volume 59, Issue 9, Page 1963-1978, September 2026.
ABSTRACT Aim There are few reports in the literature of multiple external invasive root resorption (EIRR) lesions in patients with systemic sclerosis (SSc), and an association between root resorption and SSc is not well established. We report the only case that comprehensively illustrates—with the combination of histopathology, cone beam computed ...
Jee‐Yun Leung, Geoffrey Heithersay, Richard Logan, Sharon Liberali   +3 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, Volume 20, Issue 8, Page 1913-1932, August 2026.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Vitamin B3 (Nicotinamide) Supplementation in Primary and Scleroderma‐Related Raynaud Phenomenon

ACR Open Rheumatology, Volume 8, Issue 8, August 2026.
Objective The aim of this study was to explore if vitamin B3 (nicotinamide) supplementation is a safe and effective adjunctive therapy for patients with primary Raynaud phenomenon (RP) and scleroderma‐related RP. The effect of nicotinamide supplementation in human patients with RP has not been studied before.
Mogeshni Govender, Natalie Tomson, Johnny Fang, Mohamed Bakry, Raymond Liu, Kathleen Morrisroe, Ross Penglase, Kokum Dissanayake, Ted Tsai   +8 more
wiley   +1 more source