Results 81 to 90 of about 27,956 (253)

Comparative transcriptional profiling of key macrophage and fibroblast subpopulations in rheumatoid arthritis‐associated lung disease

Arthritis &Rheumatology, Accepted Article.
Objective Rheumatoid arthritis (RA) often involves extra‐articular complications, including interstitial lung disease (ILD) and/or pulmonary nodules. Transcriptomic profiling of lung tissue provides the opportunity to directly assess cell‐specific gene expression and corresponding pathway activation in different types of rheumatoid lung disease ...
Tracy Tabib, Ogechukwu Ezenwa, Joshua Sciurba, Eleanor B. Valenzi, John Sembrat, Brittany Cody, Jishnu Das, Robert Lafyatis, Dana P. Ascherman   +8 more
wiley   +1 more source

Inflamação das vias aéreas e envolvimento pulmonar intersticial na esclerose sistêmica: associação com alterações esofágicas e microaspiração [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, 2012INTRODUCAO: O envolvimento pulmonar na Esclerose Sistemica (ES) tem sido associado com refluxo ...
Zimmermann, Adriana Fontes.
core  

[Microstomia as a complication of scleroderma]

, 2003
Scleroderma is a rare connective tissue disease of unknown origin. It is characterized by increased collagen deposition leading to fibrosis and degeneration of the skin and sometimes of internal organs.
Baat, C. de, Baat, P. de, Phoa, K.H.
core   +1 more source

Time-Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism. [PDF]

Adv Sci (Weinh)
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xia X, Kong C, Zhao X, Shi N, Jiang J, Li P.   +5 more
europepmc   +2 more sources

GLP‐1 Receptor Agonists and Endoscopy: Understanding Gastric Stasis, Aspiration Risk, and Contemporary Peri‐Procedural Guidance

Chronic Diseases and Translational Medicine, EarlyView.
Pharmacological mechanisms and physiologic effects of GLP‐1 receptor agonists relevant to peri‐endoscopic risk. ABSTRACT The global increase in obesity, type 2 diabetes mellitus (T2DM), and metabolic dysfunction‐associated steatotic liver disease (MASLD) has led to a higher use of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) among patients ...
Junaid Beig, Jason Ta, Sophie Jones, Emily Scott, Khalid Sofi, Frances Osler, Marije Jansen, Puneet Chhabra   +7 more
wiley   +1 more source

Diagnosing and Managing Linear Scleroderma in a Low-Resource Setting

, 2023
Background. Linear scleroderma is one of the five forms of scleroderma, but it is the most common form of localized scleroderma in childhood. If left untreated, it can lead to severe disfigurement and functional impairment.
Pauravy Men, Gwenyth Fischer, Sreyleak Luch, Andrew Wu   +3 more
core   +1 more source

Association of Childhood Acute Leukemia With Autoimmune Diseases

International Journal of Cancer, EarlyView.
A possible link exists between various pediatric autoimmune diseases (AIDs) and increased risk of childhood leukemia. Although immune dysregulation is a key feature of these conditions, the connection between them remains unclear. In this study, using cancer registry data in Finland, the authors examined associations between AIDs and childhood acute ...
Ida Pellikka, Julia Ventelä, Anssi Auvinen, Olli Lohi, Atte Nikkilä   +4 more
wiley   +1 more source

Scleroderma

, 2017
Scleroderma, also known as sclerosis, is an autoimmune disease causing fibrosis in connective tissues. Symptoms include: skin tightening, stiffness and swelling of fingers, weight loss, fatigue, and musculoskeletal pain.
Lawson, Erika
core  

Vascular Changes in Bleomycin-Induced Scleroderma

, 2011
Systemic sclerosis (SSc) is characterized by vascular injury, immunological abnormalities, and fibrosis of the skin as well as various internal organs. Vascular impairment is the early manifestation and plays a fundamental role in the pathogenesis of SSc.
Ichiro Katayama, Toshiyuki Yamamoto
core   +1 more source

Characterization of Pulmonary Functional Abnormalities in Systemic Sclerosis Using Xenon MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Xenon MRI is increasingly used to evaluate patients with interstitial lung disease (ILD) and pulmonary hypertension (PH), both of which are common manifestations of systemic sclerosis (SSc). As such, Xe‐MRI may be suited to interrogate lung function impairment in SSc.
Dawson Shaver, Steven Haworth, Evan Graumann, Bradie Frizzell, David H. Lee, Jiwoong Choi, Chase S. Hall, Scott M. Matson, Mark Hamblin, Mario Castro, Paul S. Schmidt, Peter J. Niedbalski   +11 more
wiley   +1 more source