Age, sex, and estrogen loss are widely recognized risk factors for Alzheimer's disease. Here, we show that brain‐specific aromatase knockout (bArKO) and the resulting estrogen loss lead to memory impairment, reduced social interaction, and extracellular environment dysregulation selectively in aged female mice, but not in young female or male mice ...
Natalie C. Piehl +12 more
wiley +1 more source
Nailfold video capillaroscopy in patients with suspected systemic sclerosis: a comparison of one-finger method versus eight-finger method. [PDF]
Doornewaard L +3 more
europepmc +1 more source
Summary Dynamic interactions between mutated haematopoietic cells and immune cells are key drivers of myelodysplastic neoplasms (MDS) initiation and progression. Regulatory T cells (Tregs) are central mediators of immunosuppression in MDS. We thus aimed to characterize Treg subpopulations in the bone marrow (BM) of MDS patients and to explore their ...
Romain Vazquez +18 more
wiley +1 more source
Late-Onset En Coup de Sabre: A Rare Presentation of Linear Scleroderma in an Elderly Woman. [PDF]
Jasim N +4 more
europepmc +1 more source
From Hair to Healing: Follicular Unit Transplantation for Chronic Ulcer Management—A Case Series
ABSTRACT Scalp follicular unit (FU) transplantation is a highly effective yet underutilised minimally invasive technique for promoting healing in chronic and recalcitrant cutaneous wounds. In this case series, five patients with long‐standing nonhealing leg ulcers of mixed etiologies were treated exclusively with single FU grafts harvested from the ...
Francisco Jimenez +4 more
wiley +1 more source
Exploring the Role of Skin Microbiota in Autoimmune Skin Diseases from a Bidirectional Mendelian Randomization Perspective. [PDF]
Wang J +6 more
europepmc +1 more source
Post‐Inflammatory Hyperpigmentation: Molecular Mechanisms and Advances in Dermocosmetic Management
ABSTRACT Background Post‐inflammatory hyperpigmentation (PIH) is a condition that causes skin pigmentation after acute or chronic inflammation. It affects people with darker skin tones more than others, especially Asians (Fitzpatrick types III–VI), and can last for months or even years, making life much less enjoyable.
Rui Li +10 more
wiley +1 more source
Pruritus associated with systemic sclerosis: a systematic review of treatment-based clinical trials. [PDF]
Mortezaei K +9 more
europepmc +1 more source
ABSTRACT Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is a form of monoclonal gammopathy of renal significance (MGRS) in which monoclonal immunoglobulin deposits are found within the glomerulus, without involvement of other renal compartments.
Hayley J. Duxbury +5 more
wiley +1 more source
Knowledge and perceptions of medical practitioners on the role of nutrition in systemic sclerosis. [PDF]
Efthymiou E +9 more
europepmc +1 more source

