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MicroRNA Expression Abnormalities in Limited Cutaneous Scleroderma and Diffuse Cutaneous Scleroderma
Journal of Clinical Immunology, 2012Scleroderma (systemic sclerosis, SSc) is a complex autoimmune disease caused by progressive fibrotic replacement of normal tissue architecture, a progressive and ultimately fatal process that currently has no cure. Although dysregulation of microRNAs (miRNAs) is known to be involved in a variety of pathophysiologic processes, the role of miRNAs in SSc ...
Honglin, Zhu +9 more
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Antimitochondrial Antibodies and Their Significance in Diffuse and Limited Scleroderma
JCR: Journal of Clinical Rheumatology, 1999The increased prevalence of primary biliary cirrhosis (PBC) in Sjogren's syndrome and scleroderma has been described. We determined the frequency of antimitochondrial antibodies (AMA) in limited scleroderma, compared with diffuse scleroderma, and have considered their clinical significance because they are known to be related to PBC.
J E, Pope, A, Thompson
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Caring for the Patient With Limited Systemic Scleroderma
Orthopaedic Nursing, 2016Systemic scleroderma (systemic sclerosis) is a rare, autoimmune, collagen-vascular disease of unknown etiology that affects the connective tissues of the skin, internal organs, as well as the small blood vessels. There are 3 subclasses of systemic scleroderma: limited cutaneous, diffuse cutaneous, and sine scleroderma.
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Prevalence of Pulmonary Hypertension in Limited and Diffuse Scleroderma
Chest, 1996To characterize the prevalence of undiagnosed pulmonary hypertension in patients with limited and diffuse scleroderma.Prospective cross-sectional study.University-based outpatient clinic.Thirty-four consecutive patients with limited (n = 29) or diffuse (n = 5) scleroderma but without the clinical diagnosis of pulmonary hypertension.All patients had 12 ...
R W, Battle +6 more
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Effects of olopatadine in limited scleroderma with peripheral eosinophils
Geriatrics & Gerontology International, 2008Scleroderma and eosinophilia often occur together, though the pathogenesis is unclear. We investigated the effect of olopatadine hydrochloride in a series of cases of limited scleroderma (LS). Ten patients with LS and positive eosinophil counts (LSE) were enrolled (average age, 85 years; six men and four women).
Motoo, Kikuchi +4 more
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Diffuse and limited cutaneous systemic scleroderma
Current Opinion in Rheumatology, 2000Juvenile systemic scleroderma (jSSc) is a rare disease. Based on the first large data collection on this patient group, the disease course was demonstrated to differ from that in adults. The concept of persistence of maternal cells in patients with SSc remains pathogenetically fascinating, as does the resemblance with graft-versus-host-disease. In view
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Fibrillary glomerulonephritis associated with limited scleroderma: a case report
Clinical Nephrology, 2016Fibrillary glomerulonephritis (GN) is a rare glomerular disorder that has been associated with monoclonal gammopathies, malignancies, chronic infections, and autoimmune disorders. We present the case of a 56-year-old woman with limited-type scleroderma and remote discoid lupus, evaluated for dipstick positive hematuria and preserved kidney function ...
Georges N, Nakhoul, James F, Simon
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Critical Appraisal of the Utility and Limitations of Animal Models of Scleroderma
Current Rheumatology Reports, 2015Scleroderma, also called systemic sclerosis (SSc), is an autoimmune connective tissue disease characterized by abnormality of the immune system, cardiovascular disorder, and fibrosis of the skin, lung, kidney, and other internal organs. Skin symptom and stiffness of the skin with accumulation of collagen cause severe disability, and cardiovascular and ...
Kazuyuki, Tsujino, Dean, Sheppard
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AB0808 L-selectin is associated with skin damage in diffuse scleroderma but not limited scleroderma
Annals of the Rheumatic Diseases, 2012Background Systemic sclerosis (SSc) is an inflammatory obliterative microvasculopathy disorder of unknown etiology characterized by fibrosis predominantly in the dermis but also in internal organs. The selectin family of adhesion molecules is responsible for the early stages of extravasation through leukocyte adhesion and recruitment involving initial
J.V. Dunne, S.F. van Eeden, K.J. Keen
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