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Immunopathogenesis of Pediatric Localized Scleroderma [PDF]
Frontiers in Immunology, 2019 Localized scleroderma (LS) is a complex disease characterized by a mixture of inflammation and fibrosis of the skin that, especially in the pediatric population, also affects extracutaneous tissues ranging from muscle to the central nervous system ...
Kathryn S. Torok +11 more
doaj +4 more sources
Pediatric Rheumatology Online Journal, 2023 Background Juvenile localized scleroderma (LS) and systemic sclerosis (SSc) are rare pediatric conditions often associated with severe morbidities. Delays in diagnosis are common, increasing the risk for permanent damage and worse outcomes.
Leigh A. Stubbs +20 more
doaj +2 more sources
Successful treatment of localized scleroderma using brodalumab: A case report [PDF]
SAGE Open Medical Case ReportsWe report the first documented use of brodalumab, an IL-17 receptor antagonist, for treating severe linear localized scleroderma refractory to conventional therapies, including methotrexate, mycophenolate mofetil and corticosteroids.
Alexandra Carla Bobica +4 more
doaj +2 more sources
Juvenile localized scleroderma: a large retrospective cohort study from a tertiary care center [PDF]
Pediatric Rheumatology Online JournalBackground Juvenile localized scleroderma is a rare pediatric inflammatory disease that primarily affects the skin and subcutaneous tissue but also has the potential to impact deeper tissues and can be associated with extracutaneous manifestations ...
Bugra Han Egeli +8 more
doaj +2 more sources
Case Report: Exacerbation after fat grafting in patients with active localized scleroderma [PDF]
Frontiers in SurgeryBackgroundThe application of autologous fat transplantation in facial lesions of patients with localized scleroderma (LoS) has been reported in recent years.ObjectiveThe authors report a case of worsening of active localized scleroderma after autologous ...
Shunxin Han +3 more
doaj +2 more sources
Endpoints and outcomes for localized scleroderma/morphea: a scoping literature review [PDF]
Pediatric Rheumatology Online JournalBackground Current treatment for localized scleroderma (LS) has been shown to halt disease activity, but little is still known about patient experiences with these treatments, nor is there consensus about optimal measurement strategies for future ...
Alexy Hernandez +5 more
doaj +2 more sources
Evaluation of Thiol Disulfide, Ischemia Modified Albumin, and Prolidase Parameters in Patients With Localized Scleroderma [PDF]
Dermatology Practical & ConceptualIntroduction: Localized scleroderma is a rare inflammatory skin disease that causes sclerosis in the dermis and subcutaneous tissue. Oxidative stress may play a role in the etiology or be responsible for the chronicity or progression of the disease ...
Ayşe Akbaş +5 more
doaj +2 more sources
International Journal of Molecular Sciences, 2023 Localized scleroderma (LS) is an autoimmune disease with both inflammatory and fibrotic components causing an abnormal deposition of collagen in the skin and underlying tissue, often leading to disfigurement and disability. Much of its pathophysiology is
Giffin Werner +7 more
semanticscholar +1 more source
Localized scleroderma: clinical spectrum and therapeutic update [PDF]
Anais Brasileiros de Dermatologia, 2015 Scleroderma is a rare connective tissue disease that is manifested by cutaneous sclerosis and variable systemic involvement. Two categories of scleroderma are known: systemic sclerosis, characterized by cutaneous sclerosis ...
Mariana Figueiroa Careta, Ricardo Romiti
doaj +2 more sources
Application of an iPSC‐Derived Organoid Model for Localized Scleroderma Therapy
Advancement of science, 2022 Localized scleroderma (LoS) is a rare chronic disease with extensive tissue fibrosis, inflammatory infiltration, microvascular alterations, and epidermal appendage lesions.
Jie Ma +16 more
semanticscholar +1 more source