Phosphodiesterase-4 inhibition in localized scleroderma: A case series of topical roflumilast [PDF]
SAGE Open Medical Case ReportsLocalized scleroderma, or morphea, is a chronic fibrosing skin condition with limited therapeutic options, particularly for patients who are elderly, immunocompromized, or intolerant to systemic immunosuppressants.
Ghassan Barnawi +4 more
doaj +2 more sources
High-content Image-based Drug Testing of Patients’ Primary Fibroblasts Reveals Potential New Treatment Options for Localized Scleroderma [PDF]
Acta Dermato-VenereologicaLocalized scleroderma is a rare autoimmune disease characterized by progressive fibrosis of the skin and its underlying structures, causing loss of normal tissue structure and function.
Katariina Mähönen +10 more
doaj +2 more sources
Successful treatment of localized scleroderma using brodalumab: A case report [PDF]
SAGE Open Medical Case ReportsWe report the first documented use of brodalumab, an IL-17 receptor antagonist, for treating severe linear localized scleroderma refractory to conventional therapies, including methotrexate, mycophenolate mofetil and corticosteroids.
Alexandra Carla Bobica +4 more
doaj +2 more sources
Revealing Microvascular Involvement in Pediatric Localized Scleroderma Through Nailfold Capillaroscopy [PDF]
ChildrenBackground/Objectives: Juvenile localized scleroderma (jLoS) is a chronic inflammatory disorder with skin and subcutaneous tissue involvement. Microvascular alterations are thought to contribute to its pathogenesis.
Sema Nur Taşkın +5 more
doaj +2 more sources
Juvenile localized scleroderma: a large retrospective cohort study from a tertiary care center [PDF]
Pediatric Rheumatology Online JournalBackground Juvenile localized scleroderma is a rare pediatric inflammatory disease that primarily affects the skin and subcutaneous tissue but also has the potential to impact deeper tissues and can be associated with extracutaneous manifestations ...
Bugra Han Egeli +8 more
doaj +2 more sources
Localized scleroderma: clinical spectrum and therapeutic update [PDF]
Anais Brasileiros de Dermatologia, 2015 Scleroderma is a rare connective tissue disease that is manifested by cutaneous sclerosis and variable systemic involvement. Two categories of scleroderma are known: systemic sclerosis, characterized by cutaneous sclerosis ...
Mariana Figueiroa Careta, Ricardo Romiti
doaj +2 more sources
Вопросы современной педиатрии, 2020 The localized scleroderma (morphea) is the clinical option of the juvenile scleroderma, the third in prevalence rheumatic condition in pediatrics. The article summarizes all the data on the classification, diagnostics, and differential diagnosis of ...
Rinat K. Raupov +2 more
doaj +1 more source
Localized scleroderma in children
Przegląd Dermatologiczny, 2020 Localized scleroderma is an autoimmune disease affecting the dermis and underlying tissues (subcutaneous tissue, fascia, muscles, bones). The disease mainly occurs in women aged 20–50 years; however, children aged 7–10 years represent about 15% of all ...
Katarzyna A. Wolska-Gawron +1 more
doaj +1 more source
Detection of autoimmune antibodies in localized scleroderma by synthetic oligonucleotide antigens. [PDF]
PLoS ONE, 2018 In this study, we developed a series of synthetic oligonucleotides that allowed us to investigate the details on the antigen recognition by autoimmune antibodies in localized scleroderma subjects.
Simone Samuelsen +4 more
doaj +1 more source
Laser therapy in superficial morphea lesions – indications, limitations and therapeutic alternatives [PDF]
, 2020 Morphea or localized scleroderma is an uncommon autoimmune and inflammatory disease which affects patients of any age. Even if morphea lesions present systemic symptoms as myalgias or arthritis, it is distinct from systemic sclerosis because it does not ...
Ardeleanu, Valeriu +4 more
core +2 more sources