Results 1 to 10 of about 55,092 (221)

Phosphodiesterase-4 inhibition in localized scleroderma: A case series of topical roflumilast [PDF]

SAGE Open Medical Case Reports
Localized scleroderma, or morphea, is a chronic fibrosing skin condition with limited therapeutic options, particularly for patients who are elderly, immunocompromized, or intolerant to systemic immunosuppressants.
Ghassan Barnawi, Alexandra Carla Bobica, Hessah BinJadeed, Stephanie Ghazal, Elena Netchiporouk   +4 more
doaj   +2 more sources

A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. [PDF]

, 2015
In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of ...
Abraham, D, Ahmed-Abdi, B, Denton, C, Lafyatis, R, Layne, MD, Nikitorowicz-Buniak, J, Ponticos, M, Shiwen, X, Smith, BD, Stratton, R, Suki, B, Takahashi, A   +11 more
core   +12 more sources

Proteomic aptamer analysis reveals serum markers that characterize preclinical systemic sclerosis (SSc) patients at risk for progression toward definite SSc

Arthritis Research & Therapy, 2023
Background The study of molecular mechanisms characterizing disease progression may be relevant to get insights into systemic sclerosis (SSc) pathogenesis and to intercept patients at very early stage.
Chiara Bellocchi, Shervin Assassi, Marka Lyons, Maurizio Marchini, Chandra Mohan, Alessandro Santaniello, Lorenzo Beretta   +6 more
doaj   +1 more source

Fibrosing arthropathy in juvenile scleroderma

Современная ревматология, 2021
The group of scleroderma diseases includes a number of clinical entities, the main symptom of which is skin tightening. Scleroderma is a prominent example of these diseases, characterized by excessive synthesis and deposition of collagen in organs and ...
D. A. Dibrov, M. N. Starovoitova, O. V. Desinova   +2 more
doaj   +1 more source

Localized scleroderma: clinical spectrum and therapeutic update [PDF]

Anais Brasileiros de Dermatologia, 2015
Scleroderma is a rare connective tissue disease that is manifested by cutaneous sclerosis and variable systemic involvement. Two categories of scleroderma are known: systemic sclerosis, characterized by cutaneous sclerosis ...
Mariana Figueiroa Careta, Ricardo Romiti
doaj   +2 more sources

Cultural adaptation and validation of the scleroderma health assessment questionnaire into Arabic language

Egyptian Rheumatology and Rehabilitation, 2023
Background Systemic sclerosis is an autoimmune multisystem disorder which affects the patients’ physical and psychological functioning. Scleroderma health assessment questionnaire used to measure physical disability in systemic sclerosis patients.
Samah Mahmoud Alian, Enass Abdel-kader Eliwa, Sohair Atia Ahmed, Manar Ibrahim Abd El-Fattah Ibrahim   +3 more
doaj   +1 more source

A case of scleroderma-like lesions as a cutaneous manifestation of carcinoid syndrome

Current Problems in Cancer: Case Reports, 2022
Scleroderma-like lesions are a rare sign of carcinoid syndrome which have been associated with poor prognosis. They differ from systemic sclerosis by involving preferentially the skin in the lower limbs, lacking Raynaud's phenomenon and having no ...
João Boavida Ferreira, Sara Magno, Joaninha Costa Rosa, António Guimarães, Fernanda Sachse, Margarida Brito   +5 more
doaj   +1 more source

Renal Involvement in Systemic Sclerosis: An Update

Kidney & Blood Pressure Research, 2020
Background: Systemic sclerosis is an immune-mediated rheumatic disease characterized by vascular abnormalities, tissue fibrosis and autoimmune phenomena.
Magdalena Chrabaszcz, Jolanta Małyszko, Mariusz Sikora, Rosanna Alda-Malicka, Anna Stochmal, Joanna Matuszkiewicz-Rowinska, Lidia Rudnicka   +6 more
doaj   +1 more source

Preliminary safety and efficacy profile of prucalopride in the treatment of systemic sclerosis (SSc)-related intestinal involvement: results from the open label cross-over PROGASS study

Arthritis Research & Therapy, 2017
Background Prokinetics are used to treat enteric dismotility symptoms in systemic sclerosis (SSc) patients, but they often lack adequate efficacy. The most effective prokinetics belonging to the serotonin (5-HT4) receptor agonists class were withdrawn ...
Barbara Vigone, Monica Caronni, Adriana Severino, Chiara Bellocchi, Anna Rita Baldassarri, Mirella Fraquelli, Gaia Montanelli, Alessandro Santaniello, Lorenzo Beretta   +8 more
doaj   +1 more source

Refractory scleroderma renal crisis precipitated after high-dose oral corticosteroids and concurrent intravitreal injection of bevacizumab

SAGE Open Medical Case Reports, 2020
Scleroderma renal crisis is a serious complication that can develop in certain patients with systemic sclerosis. Some risks have been identified as potential triggers of scleroderma renal crisis, including the high-dose oral corticosteroids.
Ramy M Hanna, Lama Abdelnour, Jonathan E Zuckerman, Antoney J Ferrey, Alex Pai, Kambiz Vahabzadeh, James Wilson, Everado A Torres, Kamyar Kalantar-Zadeh, Ira B Kurtz   +9 more
doaj   +1 more source