Results 1 to 10 of about 1,261,715 (219)

Sine scleroderma, limited cutaneous, and diffused cutaneous systemic sclerosis survival and predictors of mortality

Arthritis Research & Therapy, 2021
Highlights • Male sex, cardiac involvement, DLCO 5 mg/l are strong predictors of mortality in systemic sclerosis. • This study shows the survival of subtypes and in particular sine scleroderma. • Sine scleroderma subtype has better survival than diffuse
Sébastien De Almeida Chaves, Tiphaine Porel, Mickael Mounié, Laurent Alric, Léonardo Astudillo, Antoine Huart, Olivier Lairez, Martin Michaud, Grégoire Prévot, David Ribes, Laurent Sailler, Francis Gaches, Daniel Adoue, Gregory Pugnet   +13 more
doaj   +2 more sources

Localized Scleroderma, Systemic Sclerosis and Cardiovascular Risk: A Danish Nationwide Cohort Study

Acta Dermato-Venereologica, 2017
Recent findings indicate that patients with systemic sclerosis have an increased risk of cardiovascular disease. To determine whether patients with systemic sclerosis or localized scleroderma are at increased risk of cardiovascular disease, a cohort ...
Jeanette Halskou Hesselvig, Kristian Kofoed, Jashin J. Wu, Lene Dreyer, Gunnar Gislason, Ole Ahlehoff   +5 more
doaj   +2 more sources

Systemic sclerosis sine scleroderma [PDF]

Advances in Clinical and Experimental Medicine, 2017
Systemic sclerosis is a rare generalized disease with scleroderma, i.e. skin thickening as one of the most common symptoms. The disease has 2 main subsets, diffuse and limited forms. The subset known as systemic sclerosis sine scleroderma (ssSSc) is a very rare subset characterized by the total or partial absence of cutaneous manifestations of systemic
Eugeniusz J, Kucharz, Magdalena, Kopeć-Mędrek   +1 more
openaire   +3 more sources

Phosphodiesterase-4 inhibition in localized scleroderma: A case series of topical roflumilast [PDF]

SAGE Open Medical Case Reports
Localized scleroderma, or morphea, is a chronic fibrosing skin condition with limited therapeutic options, particularly for patients who are elderly, immunocompromized, or intolerant to systemic immunosuppressants.
Ghassan Barnawi, Alexandra Carla Bobica, Hessah BinJadeed, Stephanie Ghazal, Elena Netchiporouk   +4 more
doaj   +2 more sources

Pathogenesis of Scleroderma (Systemic Sclerosis)

Journal of Investigative Dermatology, 1982
Increasing interest in the vascular features of scleroderma has led to the hypothesis that the blood vessel is the major target tissue and that the endothelial cell is the principal cell target. Useful observations stemming from the vascular hypothesis include the use of microvascular abnormalities in the early detection of the patient destined to ...
E. LeRoy
openaire   +3 more sources

Systemic Scleroderma

The Medical clinics of North America, 2010
Jennyy Sun, Gillian Lieberman, Jennyy Sun, Gillian Liberman   +3 more
openaire   +2 more sources

Pathophysiology of systemic sclerosis (scleroderma)

Kaohsiung Journal of Medical Sciences, 2022
Systemic sclerosis (scleroderma) is an autoimmune‐triggered chronic fibrosing disease that affects the skin and many other organs. Its pathophysiology is complex and involves an early endothelial damage, an inflammatory infiltrate and a resulting ...
A. Rosendahl, K. Schönborn, T. Krieg
semanticscholar   +1 more source

Proteomic aptamer analysis reveals serum markers that characterize preclinical systemic sclerosis (SSc) patients at risk for progression toward definite SSc

Arthritis Research & Therapy, 2023
Background The study of molecular mechanisms characterizing disease progression may be relevant to get insights into systemic sclerosis (SSc) pathogenesis and to intercept patients at very early stage.
Chiara Bellocchi, Shervin Assassi, Marka Lyons, Maurizio Marchini, Chandra Mohan, Alessandro Santaniello, Lorenzo Beretta   +6 more
doaj   +1 more source

Renal Disease and Systemic Sclerosis: an Update on Scleroderma Renal Crisis

Clinical reviews in allergy and immunology, 2022
Scleroderma renal crisis (SRC) is a life-threatening complication of systemic sclerosis (SSc) with a mortality of 20% at 6 months. Once the leading cause of mortality in scleroderma (SSc), it remains a serious complication, often necessitating level ...
Alice Cole, V. Ong, C. Denton
semanticscholar   +1 more source

Systemic Scleroderma—Definition, Clinical Picture and Laboratory Diagnostics

Journal of Clinical Medicine, 2022
(1) Background: Scleroderma (Sc) is a rare connective tissue disease classified as an autoimmune disorder. The pathogenesis of this disease is not fully understood. (2) Methods: This article reviews the literature on systemic scleroderma (SSc).
Anna Kowalska-Kępczyńska
semanticscholar   +1 more source