Results 121 to 130 of about 55,245 (231)

Antiphospholipid Syndrome Coexisting With Evans Syndrome and SCL‐70 Antibody Positivity: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT This case of antiphospholipid syndrome, Evans syndrome, and anti‐Scl‐70 positivity (suggesting early SSc) showed marked symptom improvement with rituximab, but poor prognosis persists. Highlights the need for early diagnosis of overlapping autoimmunity, SSc complication monitoring, and optimized immunotherapy in complex cases.
Chunhua Cao, Xiaodong Hu, Zian Li, Deqing Li, Jideng Ma   +4 more
wiley   +1 more source

Rituximab and Intravenous Immunoglobulin (IVIG) for Refractory Eosinophilic Fasciitis: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Eosinophilic fasciitis (EF) is a rare condition with an unknown cause. This case study showed that a 40‐year‐old man with EF did not respond to standard treatments but improved after receiving rituximab and intravenous immunoglobulin (IVIG). Further studies are needed to confirm rituximab's effectiveness and long‐term safety for EF.
Maryam Sahebari, Motahhareh Karimoddini, Naser Tayyebi Meibodi, Sajad Ataei Azimi, Shadan Tafreshian   +4 more
wiley   +1 more source

Bosentan Does Not Affect Renal Resistive Index in Scleroderma/Systemic Sclerosis Patients.

Kidney Blood Press Res, 2023
Di Poi E, Colussi G, Bertoni M, Giovannini I, Tolusso B, Ferraccioli GF, Gremese E, De Vita S, Romano G.   +8 more
europepmc   +1 more source

Caplan Syndrome: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
Swelling of metacarpophalangeal joints, proximal interphalangeal joints with spindle‐shaped aspects at proximal interphalangeal joints. ABSTRACT Caplan syndrome, known as rheumatoid pneumoconiosis, is a combination of silicosis and rheumatoid arthritis.
Ali Moussa Mahaman Laouali, Maïga Soumaila, Ismael Ayouba Tinni, Ngo Ngue Tecler Clémence, Zoundi Lydia Rosine, Ousmane Dembélé, Soubeiga Dimitri, Essaga Eloundou Christèle, Moussa Rahanatou, Issa Ouédraogo, Boncoungou Kadiatou, Badoum Giselle, Ouédraogo Martial   +12 more
wiley   +1 more source

Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions

MedComm, Volume 7, Issue 1, January 2026.
The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin, Jiahui Wang, Runyi Cao, Dongsheng Jiang   +3 more
wiley   +1 more source

A Rare Case of Juvenile Systemic Sclerosis: Clinical Challenges and Management

Annals of Rheumatology and Autoimmunity
Scleroderma is “skleros” sclerosing or hardening of the “derma” skin. It includes both systemic and localized scleroderma (LS). Mostly, juvenile LS affects the skin, whereas juvenile systemic sclerosis (SSc) involves multiple organ systems.
Areej Bano, Shalini Verma, Shrish Bhatnagar   +2 more
doaj   +1 more source

Obesity as a Risk Factor for Autoimmune Diseases: A Systematic Review and Meta‐Analysis

Obesity, Volume 34, Issue 1, Page 36-50, January 2026.
Summary of the meta‐analysis including 26 studies (8 cross‐sectional, 18 longitudinal) investigating the association between obesity and autoimmune diseases. Findings show increased prevalence and incidence of rheumatoid arthritis, psoriasis, multiple sclerosis, and inflammatory bowel diseases in people with obesity, suggesting that obesity may ...
Ilaria Spatocco, Giorgia Mele, Giusy De Rosa, Clorinda Fusco, Kristyna Ruggiero, Valeria Pellegrini, Francesca Carreras, Rosalba La Grotta, Antonio Ceriello, Claudio Procaccini, Giuseppe Matarese, Francesco Prattichizzo, Paola de Candia   +12 more
wiley   +1 more source

Pathogenesis of Scleroderma (Systemic Sclerosis)

Journal of Investigative Dermatology, 1982
Increasing interest in the vascular features of scleroderma has led to the hypothesis that the blood vessel is the major target tissue and that the endothelial cell is the principal cell target. Useful observations stemming from the vascular hypothesis include the use of microvascular abnormalities in the early detection of the patient destined to ...
openaire   +2 more sources

Assessing Recurrent Acute Rhinosinusitis Development in Posttransplant Patients: A Study on Sinus Surgery Necessity

OTO Open, Volume 10, Issue 1, January-March 2026.
Abstract Objective Recurrent acute rhinosinusitis (RARS) significantly decreases quality of life. Transplant recipients (TR) are particularly vulnerable to rhinologic conditions. There is a lack of guidelines for managing RARS in this population. Our study aims to determine the prevalence of and risk factors for RARS among TR and assess the need for ...
Estephania Candelo, Anyull Dayanna Bohorquez‐Caballero, Angela M. Donaldson   +2 more
wiley   +1 more source

Isolated Anti‐SS‐A Antibody Seropositivity as a Poor Prognostic Factor in Systemic Sclerosis: Insights From a Cohort of 307 Cases

The Journal of Dermatology, Volume 53, Issue 1, Page 41-53, January 2026.
ABSTRACT Systemic sclerosis is an autoimmune disease characterized by vasculopathy, fibrosis, and immune dysregulation. Anti‐SS‐A antibodies (anti‐SSA) have been reported to confer severe clinical manifestations in some Western and Japanese cohorts. We aimed to determine whether anti‐SSA seropositivity affects clinical outcomes in Japanese patients. We
Nana Ishida, Kazuki M. Matsuda, Hirohito Kotani, Hayakazu Sumida, Shinichi Sato   +4 more
wiley   +1 more source